Why do People Have Hypertensive Nephropathy
Hypertensive Nephropathy is a term in clinic, which is diagnosed by the index in clinic. In recent years, with the development of cytology, Hypertensive Nephropathy is caused by long time high blood pressure due to insufficiency of blood in renal endothelial cell.
The pathogenesis of Hypertensive Nephropathy is as follows: due to insufficiency in blood, high blood pressure causes damage in the kidney. In addition, it is also caused by the hyperfiltration and high TMP in renal glomeruli. With the continuous development of high blood pressure and the structure damage in renal arteries, the wall of tubules become thicker, which leads to the decrease of renal blood flow, thus causing insufficiency of blood and oxygen in the renal capillary endothelial cell. After the capillary endothelial cells are damaged, the activity of anticoagulation will also decrease, which promotes the gathering of blood cells and take part in the form of thrombosis. After the endothelial cells are activated, phenotype changes, which releases a series of cell factors to attract the infiltration of inflammatory cells. In this case, the filtration barrier is damaged. Protein will leak out, which leads to the start of renal fibrosis. At this time, a series of symptoms such as proteinuria, edema, increased urine at night will appear.