FSGS is a medical term used to describe the appearance of the kidney tissues on biopsy. Routine urine test and routine blood test help to found out how well the kidney functions, but fail to show the pathological changes. Renal biopsy is a gold standard to know kidney damages well, but disappointedly, it causes kidney damages while works. Therefore, renal biopsy usually is not recommended, especially for kidney failure patients.
In the diagnosis for FSGS, it should be identified with the traditional Minimal Change Disease(MCD). Paying attention to the following aspects is helpful for the diagnosis of FSGS. First, hypertension and renal function damage are nearly accompanied by the onset of the FSGS, which is more common seen in FSGS than in MCD. And this is more obvious in adult patients.
Second, the morbidity rate for microscopic haematuria in FSGS is also higher than that in MCD patients. In fact, about 2/3 FSGS patients are accompanied by microscopic hematuria.
Third, MCD patients commonly see the selective proteinuria while FSGS patients see more unselective proteinuria.
Fourth, renal tubules damage is often accompanied by with FSGS patients.
Fifth, the level of IgG in patient blood serum is obviously lower than that lost in the urine, which indicates the lowing blood IgG level is possibly related with the patients' abnormal immune function.
4.Anti-histone Antibody: Anti-histone Antibody can be tested in Lupus Nephritis and sometime in rheumatic arthritis and Sjoegren syndrome.
Sixth, FSGS patients have a more weaker sensitivity to the hormone treatment than the MCD.
Seventh, the size of glomeruli in patients with FSGS is larger than that in MCD patients.
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