Minimal Change Nephrotic Syndrome Kidney Disorder

Minimal change disease is a kidney disorder that can lead to nephrotic syndrome, although the nephrons of the kidney look normal under a regular microscope. In minimal change disease, there is damage to the glomeruli -- the tiny blood vessels inside the nephron where blood is filtered to make urine and waste is removed. The disease gets its name because this damage is not visible under a regular microscope. It can only be seen under an electron microscope.
Minimal change disease is the most common cause of nephrotic syndrome in children. It causes about 80% of cases in young children. It is also seen in adults, but makes up only 10 to 15% of nephrotic syndrome cases.
1.20% of patients with minimal change kidney disease have various degree of microscopic hematuria. With patients aging, the morbidity of microscopic hematuria is also increasing. Especially in those aged more than 60, due to renal interstitial fibrosis and diabetic microangiopathy, the morbidity of microscopic hematuria is high. However, gross hematuria is rarely seem.
2. Protein in urine is the typical highly selective one among children, which mainly includes albumin, and a slight amount of HMWP such as IgG, α2- macroglobulin, C3, etc.
3. Poor appetite, which is also a symptom.
4. Swelling (especially around the eyes, feet, and ankles, and in the abdomen)
5. Weight gain from fluid retention is also a manifestation of minimal change kidney disorder.
If not treated well and timely, minimal change kidney disease will develop into the second level: mild change. More than half of the glomeruli appear normal and only a small part are found to have changes like mesangial cells' proliferation, glomerular sclerosis and adhension, etc.
So we should take effective treatment measures to stop it from developing. As we mentioned above, most kidney diseases are caused by immune disorder and minimal change kidney disease is not an exception. In our Hospital, we have immunotherapy, which can be divided into 6 steps: immune diagnosis, immune clearance,immune inhibition, immune tolerance, immune adjustment and immune protection. For more information, please consult us online or email us.