-
Diabetic Nephropathy can not be found out at early stage. Once it is found, it has often been in advanced stage and has deteriorated. So which factors lead to Diabetic Nephropathy? They are as follows:
The first factor is the abnormal renal haemodynamics. Renal haemodynamics plays a critical role in the coming into being of Diabetic Nephropathy. When the blood sugar is high, the pressure in capillary wall will increase, which leads to the extension of mesangial area, the fusion of foot process of epithelial cells. The epithelial cells drop from renal basilar membrane, which leads to the ultrafiltration and ultraperfusion. Basilar IV collagen messenger increase, which leads to the increased thickness of basilar membrane. At last, diffusibility and nodositas will come into being, leading to sclerosis. With the increasing of dynamic pressure of renal blood flow, the filtration of protein increases, which leads to the increase of matrix. Nodositas renal glomerular sclerosis comes into being.
The second factor is high blood sugar. In most cases, the occurrence of Diabetic Nephropathy is related to high blood sugar. When the sugar in the blood is not controlled well, high blood sugar and increased adanced glycation end products can lead to the proliferation of mesangial cells and increased matrix. The mesangial area will extend, which can lead to the occurrence of Diabetic Nephropathy.
The third factor is high blood pressure. High blood pressure has no direct connection with Diabetic Nephropathy. But in the high blood pressure stage when there is microalbunminuria, the high blood pressure can lead to the deterioration of renal function, which causes Diabetic Nephropathy.
The fourth factor is genetic factors. People whose parents have had Diabetic Nephropathy are more likely to have Diabetic Nephropathy compared with those whose parents do not have Diabetic Nephropathy.
The fifth factor is the increased blood viscosity and the block of micro-circulation. Blood viscosity and the block of micro-circulation can lead to thrombus easily. Once thrombus comes into being, renal unites will be in the insufficiency of blood and oxygen. Protein in urine will increase and renal function will decline.
The sixth factor is high protein diet. It is also a factor which can bring more burden to the kidney, and cause vicious circle. So for patients with Diabetic Nephropathy, the intake of protein should not be more than 40g.
The last factor is hyperlipidemia, which is common among those with Diabetic Nephropathy. Hyperlipidemia can promote the renal glomerular sclerosis and accelerate the development of Diabetic Nephropathy.
Friday, May 31, 2013
Which Factors Influence the Recovery of Diabetic Nephropathy
Which factors influence the recovery of Diabetic Nephropathy? As a matter of fact, diet, treatment, blood pressure and blood sugar, all the above-mentioned will influence the recovery of Diabetic Nephropathy.
Factors which can influence Diabetic Nephropathy go as follows.
1.Food
Food which is rich in protein will accelerate the development of Diabetic Nephropathy. Because patients with Diabetes limit the intake of carbohydrate and mainly choose fiber food which is rich in protein, the load from protein catabolite and phosphorus will become excessive, which will accelerate the pathological damage of Diabetic Nephropathy.
2. High blood pressure.
Due to the disorder of lipid metabolism, atherosclerosis, etc, few patients can merge high blood pressure. Nearly all patients can be found to have trace of albumin in urine, which shows that the renal damage has been serious.
3. High blood sugar
Long time and excessive increase of sugar in blood will lead to the increase of blood capillary permeability, the exosmosis of plasma protein, which causes the damage of capillary basilar membrane, renal glomerularsclerosis and shrink of renal tissues.
From the above-mentioned, we can understand what influenced the recovery of Diabetic Nephropathy. Besides these, how to treat Diabetic Nephropathy?
Patients with Diabetic Nephropathy are suggested to receive Chinese Medicine, a multi-target treatment, which can directly block the renal fibrosis according to the different critical stage. After Chinese Medicine enters patients’body, it can play roles such as extending blood vessels, anti-inflammation, anti-coagulation, and degradation, which can improve the blood supply in the kidney and other tissues and organs, stop inflammatory reaction, inhibit the form of thrombus. Besides, Chinese Medicine can also degrade the abnormal deposition of ECM. In addition, Chinese Medicine can also promote the phenotypic reversion of intrinsic cells in the kidney which had already had phenotype transformation. At the same time, Chinese Medicine can supply essential materials which are used to repair the intrinsic cells.
If necessary, in addition to Chinese Medicine, patients with Diabetic Nephropathy should also use stem cell, which can differentiate into kinds of intrinsic cells the body needs. More detailed information, please communicate with specialists on line or email us.
Factors which can influence Diabetic Nephropathy go as follows.
1.Food
Food which is rich in protein will accelerate the development of Diabetic Nephropathy. Because patients with Diabetes limit the intake of carbohydrate and mainly choose fiber food which is rich in protein, the load from protein catabolite and phosphorus will become excessive, which will accelerate the pathological damage of Diabetic Nephropathy.
2. High blood pressure.
Due to the disorder of lipid metabolism, atherosclerosis, etc, few patients can merge high blood pressure. Nearly all patients can be found to have trace of albumin in urine, which shows that the renal damage has been serious.
3. High blood sugar
Long time and excessive increase of sugar in blood will lead to the increase of blood capillary permeability, the exosmosis of plasma protein, which causes the damage of capillary basilar membrane, renal glomerularsclerosis and shrink of renal tissues.
From the above-mentioned, we can understand what influenced the recovery of Diabetic Nephropathy. Besides these, how to treat Diabetic Nephropathy?
Patients with Diabetic Nephropathy are suggested to receive Chinese Medicine, a multi-target treatment, which can directly block the renal fibrosis according to the different critical stage. After Chinese Medicine enters patients’body, it can play roles such as extending blood vessels, anti-inflammation, anti-coagulation, and degradation, which can improve the blood supply in the kidney and other tissues and organs, stop inflammatory reaction, inhibit the form of thrombus. Besides, Chinese Medicine can also degrade the abnormal deposition of ECM. In addition, Chinese Medicine can also promote the phenotypic reversion of intrinsic cells in the kidney which had already had phenotype transformation. At the same time, Chinese Medicine can supply essential materials which are used to repair the intrinsic cells.
If necessary, in addition to Chinese Medicine, patients with Diabetic Nephropathy should also use stem cell, which can differentiate into kinds of intrinsic cells the body needs. More detailed information, please communicate with specialists on line or email us.
Dry Mouth and Diabetes
Can dry mouth be connected with Diabetes? Experts say that dry mouth is really one of the symptoms of Diabetes in early stage. About 30% to 50% of patients with Diabetes can feel dry in mouth in the early stage. If the blood sugar can not be controlled well, dry mouth may become worse. They even need to drink water at midnight so as to relieve thirst.
How to deal with it according to natural treatment of traditional Chinese medicine? Diabetes patients are suggested to have medlar. To solve the problem that patients feel thirst at night, they can have 30g at night and chew them. They can also wash the medlar clean and put it on the tongue. After several seconds, there will be fluid from the root of the tongue, which can relive the thirst.
Besides these, what else can people do so as to treat Diabetes? Stem cell transplant is the latest news which is used to treat many kinds of diseases including Diabetes. As we mentioned in the premier articles, Diabetes is also a kind of immune disease.
Type 1 Diabetes is a condition in which the immune system can rapidly destroy the insulin-producing cells in the pancreas. These stem cell transplants apparently work by ‘resetting’ the immune system so that the body stops attacking the pancreas.
How to deal with it according to natural treatment of traditional Chinese medicine? Diabetes patients are suggested to have medlar. To solve the problem that patients feel thirst at night, they can have 30g at night and chew them. They can also wash the medlar clean and put it on the tongue. After several seconds, there will be fluid from the root of the tongue, which can relive the thirst.
Besides these, what else can people do so as to treat Diabetes? Stem cell transplant is the latest news which is used to treat many kinds of diseases including Diabetes. As we mentioned in the premier articles, Diabetes is also a kind of immune disease.
Type 1 Diabetes is a condition in which the immune system can rapidly destroy the insulin-producing cells in the pancreas. These stem cell transplants apparently work by ‘resetting’ the immune system so that the body stops attacking the pancreas.
Thursday, May 30, 2013
What Is Borderline Diabetes
Definition:
Borderline diabetes is also known as pre-diabetes. It is a state in which a person has higher glucose or sugar level than normal but not enough to be diagnosed as diabetic. For many people this is a symptom-free disease, so most people with pre-diabetes are unaware that they have. In a person without diabetes, the body will produce insulin to help the cells break down food into energy. In diabetics and pre-diabetics, however, either the body is unable to create insulin or it is unable to utilize the insulin. This is one reason why people with borderline diabetes tend to be tired much of the time. They are eating, but their body is unable to break down the food into usable energy. According to the American Diabetes Association, normal fasting blood sugar is lower than 100 mg/dl. A glucose level between 100 and 125 indicates pre-diabetes.
Symptoms:
Is there any symptoms when a person is suffering from borderline diabetes? Symptoms of borderline diabetes may be mild and go unnoticed until borderline diabetes turns into full-blown Type 2 diabetes. Alternatively, symptoms may be as severe as diabetes. Borderline diabetics may experience fatigue, increased thirst, hunger, mood swings, blurred vision and increased urination (both frequency and output). In addition, you may have wounds that heal more slowly and you may be prone to yeast or other opportunistic infections.
Prognosis:
Diabetes can lead to vision problems, kidney disease, heart disease and other life-threatening illnesses. If your doctor has diagnosed you with borderline diabetes/pre-diabetes, consider it a timely warning. You have the chance to change your lifestyle and possibly avoid serious complications. So preventing is necessary.
Prevention:
How to prevent borderline diabetes?
Prevent diabetes by following a diabetic diet and getting appropriate exercise for your physical condition. Losing extra pounds sometimes prevents diabetes. Even when weight loss does not entirely prevent diabetes, losing those extra pounds may prevent you from having to go on insulin or from developing serious complications associated with diabetes.
Borderline diabetes is also known as pre-diabetes. It is a state in which a person has higher glucose or sugar level than normal but not enough to be diagnosed as diabetic. For many people this is a symptom-free disease, so most people with pre-diabetes are unaware that they have. In a person without diabetes, the body will produce insulin to help the cells break down food into energy. In diabetics and pre-diabetics, however, either the body is unable to create insulin or it is unable to utilize the insulin. This is one reason why people with borderline diabetes tend to be tired much of the time. They are eating, but their body is unable to break down the food into usable energy. According to the American Diabetes Association, normal fasting blood sugar is lower than 100 mg/dl. A glucose level between 100 and 125 indicates pre-diabetes.
Symptoms:
Is there any symptoms when a person is suffering from borderline diabetes? Symptoms of borderline diabetes may be mild and go unnoticed until borderline diabetes turns into full-blown Type 2 diabetes. Alternatively, symptoms may be as severe as diabetes. Borderline diabetics may experience fatigue, increased thirst, hunger, mood swings, blurred vision and increased urination (both frequency and output). In addition, you may have wounds that heal more slowly and you may be prone to yeast or other opportunistic infections.
Prognosis:
Diabetes can lead to vision problems, kidney disease, heart disease and other life-threatening illnesses. If your doctor has diagnosed you with borderline diabetes/pre-diabetes, consider it a timely warning. You have the chance to change your lifestyle and possibly avoid serious complications. So preventing is necessary.
Prevention:
How to prevent borderline diabetes?
Prevent diabetes by following a diabetic diet and getting appropriate exercise for your physical condition. Losing extra pounds sometimes prevents diabetes. Even when weight loss does not entirely prevent diabetes, losing those extra pounds may prevent you from having to go on insulin or from developing serious complications associated with diabetes.
Is Type 2 Diabetes Tougher to Treat in Teenagers and Young Men
Type 2 Diabetes can also be called adult diabetes, which takes place when people are more than 35 to 40 years old, taking up 90% of those who are suffering diabetes. In type 2 diabetes, the ability of insulin does not get lost completely. Insulin in type 2 diabetes is relatively in insufficiency. People can take in some oral medicine to stimulate the secretion of insulin. Later, some patients still need to take insulin injection treatment. In one word, in the long run, type 2 diabetes need to control blood sugar, and make schedule on the exercise and diet.
Recently, type 2 diabetes is said to be tougher to treat in teenager and young men especially in America. Why?
A major study, released Sunday, tested several ways to manage blood sugar in teens newly diagnosed with diabetes and found that nearly half of them failed within a few years and 1 in 5 suffered serious complications. The results spell trouble for a nation facing rising rates of "diabesity" - Type 2 diabetes brought on by obesity.
The federally funded study is the largest look yet at how to treat diabetes in teens. Earlier studies mostly have been in adults, and most diabetes drugs aren't even approved for youths. The message is clear: Prevention is everything. A third of American children and teens are overweight or obese.
How to treat type 2 diabetes for teenagers effectively?
On one hand, preventing blood sugar is critical. One the other hand, stem cell is the most effective method till now to treat type 2 diabetes. It is essential cell which can renew itself and differentiate into cells the body needs after it is injected into patients’ body. How does it treat type 2 diabetes? It will repair the damaged beta cells, and diminish the resistance of insulin in the body, thus treating type 2 diabetes. In addition, if there are necrotic beta cells in the body, stem cell can differentiate into those to rebuild its function. After beta cells can be repaired or renewed, insulin can secrete normally and type 2 diabetes can be treated in teenagers and young men successfully.
Recently, type 2 diabetes is said to be tougher to treat in teenager and young men especially in America. Why?
A major study, released Sunday, tested several ways to manage blood sugar in teens newly diagnosed with diabetes and found that nearly half of them failed within a few years and 1 in 5 suffered serious complications. The results spell trouble for a nation facing rising rates of "diabesity" - Type 2 diabetes brought on by obesity.
The federally funded study is the largest look yet at how to treat diabetes in teens. Earlier studies mostly have been in adults, and most diabetes drugs aren't even approved for youths. The message is clear: Prevention is everything. A third of American children and teens are overweight or obese.
How to treat type 2 diabetes for teenagers effectively?
On one hand, preventing blood sugar is critical. One the other hand, stem cell is the most effective method till now to treat type 2 diabetes. It is essential cell which can renew itself and differentiate into cells the body needs after it is injected into patients’ body. How does it treat type 2 diabetes? It will repair the damaged beta cells, and diminish the resistance of insulin in the body, thus treating type 2 diabetes. In addition, if there are necrotic beta cells in the body, stem cell can differentiate into those to rebuild its function. After beta cells can be repaired or renewed, insulin can secrete normally and type 2 diabetes can be treated in teenagers and young men successfully.
What Causes Type 1 Diabetes
What causes Type 1 Diabetes? It is necessary to figure it out. Only when we understand the mechanism, can we treat it on the basis of the mechanism and achieve better effect. Generally, the causes can be divided into the following aspects:
1. defect of autoimmune system
In the blood of patients with Type 1 Diabetes, doctors find out kinds autoimmune antibodies such as GADA, ICA, and so on. Such abnormal antibodies can damage the beta cells which can secrete insulin and stop them from normally secreting.
2. genetic factor
At present, the research indicates that genetic factor is the pathological basis of Type 1 Diabetes. Patients with Type 1 Diabetes usually have family history. We can also say that if parents have Type 1 Diabetes, their children also have more ability of suffering from it compared with those whose parents do not have this disease.
3. infection
Infection is also an inducement which can lead to Type 1 Diabetes. Usually, before patients get symptoms of Type 1 Diabetes, they usually get infected.
4. other factors
Milk, oxygen radical and some raticide may also lead to Type 1 Diabetes. This is also under research now.
From the above mentioned, we can get a conclusion what can cause Type 1 Diabetes. If patients are diagnosed, they should take effective treatment so as to prevent it from developing and relieve the symptoms. In our Hospital, we have immunotherapy, which can repair the damaged beta cells and recover its function, thus lowering blood sugar.
1. defect of autoimmune system
In the blood of patients with Type 1 Diabetes, doctors find out kinds autoimmune antibodies such as GADA, ICA, and so on. Such abnormal antibodies can damage the beta cells which can secrete insulin and stop them from normally secreting.
2. genetic factor
At present, the research indicates that genetic factor is the pathological basis of Type 1 Diabetes. Patients with Type 1 Diabetes usually have family history. We can also say that if parents have Type 1 Diabetes, their children also have more ability of suffering from it compared with those whose parents do not have this disease.
3. infection
Infection is also an inducement which can lead to Type 1 Diabetes. Usually, before patients get symptoms of Type 1 Diabetes, they usually get infected.
4. other factors
Milk, oxygen radical and some raticide may also lead to Type 1 Diabetes. This is also under research now.
From the above mentioned, we can get a conclusion what can cause Type 1 Diabetes. If patients are diagnosed, they should take effective treatment so as to prevent it from developing and relieve the symptoms. In our Hospital, we have immunotherapy, which can repair the damaged beta cells and recover its function, thus lowering blood sugar.
Care for Type 1 Diabetes
Besides treatment, patients with Type 1 Diabetes should also pay attention to the daily care, which can assist the treatment. Most patients are youngsters and they should take care from diet, exercise, psychotherapy.
Diet:
1. energy intake
Patients should have proper amount of energy intake, which can meet the need of the body. And they should also limit the intake if the body weight is out of range.
2. protein
The intake of protein can influence the change of renal haemodynamics. Too much intake of protein can increase the burden of the kidney.
3. fibrin
The intake of fibrin can lower the blood glucose after meal. However, too much intake can also lead to discomfort in belly and influence the absorption of minerals.
4. fat
The intake of fat in a day should account for 30 to 50 of the total at most. They can also have two fish in a week.
Exercise
Exercise help patients with Type 1 Diabetes make full use of blood glucose and control the blood glucose. So patients with Type 1 Diabetes can take part in activities such as dancing, swimming. In addition, avoid climbing and diving, which are strenuous and may lead to low blood glucose, thus causing danger.
Psychotherapy
Psychotherapy also plays an important role in the recovery. So parents and friends should take care of children with Type 1 Diabetes and help them be confident that as long as the treatment is proper and they follow doctor’s advice, they can recover and live a normal life.
In addition, as for the treatment of Type 1 Diabetes, they are suggested to take immunotherapy, which is a combination therapy of Chinese traditional medicine and western medicine such as stem cell transplant. Firstly, it can give a general adjustment, improve the blood circulation, dissolve the blood stasis, improve the function of pancrease islet, thus lowing blood sugar, thus treating diabetes. Secondly, it has little side effect, compared with western medicine and can improve the life quality of patients.
Diet:
1. energy intake
Patients should have proper amount of energy intake, which can meet the need of the body. And they should also limit the intake if the body weight is out of range.
2. protein
The intake of protein can influence the change of renal haemodynamics. Too much intake of protein can increase the burden of the kidney.
3. fibrin
The intake of fibrin can lower the blood glucose after meal. However, too much intake can also lead to discomfort in belly and influence the absorption of minerals.
4. fat
The intake of fat in a day should account for 30 to 50 of the total at most. They can also have two fish in a week.
Exercise
Exercise help patients with Type 1 Diabetes make full use of blood glucose and control the blood glucose. So patients with Type 1 Diabetes can take part in activities such as dancing, swimming. In addition, avoid climbing and diving, which are strenuous and may lead to low blood glucose, thus causing danger.
Psychotherapy
Psychotherapy also plays an important role in the recovery. So parents and friends should take care of children with Type 1 Diabetes and help them be confident that as long as the treatment is proper and they follow doctor’s advice, they can recover and live a normal life.
In addition, as for the treatment of Type 1 Diabetes, they are suggested to take immunotherapy, which is a combination therapy of Chinese traditional medicine and western medicine such as stem cell transplant. Firstly, it can give a general adjustment, improve the blood circulation, dissolve the blood stasis, improve the function of pancrease islet, thus lowing blood sugar, thus treating diabetes. Secondly, it has little side effect, compared with western medicine and can improve the life quality of patients.
Wednesday, May 29, 2013
After Kidney Transplant, Would I still Have Kidney Disease
After a successful kidney transplant, would still have kidney disease? This is a question which is put forward by some patients. As a matter of fact, in many cases, kidney disease will still recur several years later. For example, diabetic nephropathy is a kind of secondary kidney disease which is caused by long time high blood sugar in the blood and immune disorder in the body. So after transplant, if these factors can not be controlled well, patients will still have possibility of getting kidney disease.
What shall we do then? The fundamental problem is that we should treat kidney disease and only in this way, can we avoid the new damage in the transplanted kidney and avoid another kidney transplant. How to treat then?
As we know, most kidney diseases are caused by immune disorder. So our focus should be aimed at adjusting the unbalanced immune system, thus increasing immune ability. On the basis of this, in our Hospital, doctors and experts created immunotherapy, which is the combination of both Chinese Medicine and western medicine and can be divided into six steps: immune diagnosis, immune clearance, immune inhibition, immune tolerance, immune adjustment and immune protection.
Through immune diagnosis, we can know where the immune complex deposits exactly and the exact type of immune response so that doctors can get more scientific diagnosis and arrange better treatment. Through immune clearance, we can clear away the immune complex in the blood, which can supply a cleaner inner environment for the treatment of kidney disease. The third one is immune inhibition. There is immune complex deposit onto kidney, which leads to immune response. In this case, we use medicine which can stop the excessive immune response, thus stopping the inflammation response at a rapid speed.
After that, patients will come into immune tolerance and immune adjustment stage. In adjustment stage in particular, many effective medicines are used such as Chinese Medicine, which is used to clear away the immune complex which deposits onto kidney, which is very critical. In the last step, stem cell therapy is also applied, which is used to repair damaged intrinsic cells, differentiate into necrotic cells and increase the immune ability at the same time.
From the above, we can know that after these steps, the transplanted kidney can avoid getting damaged, thus preventing from kidney disease once more.
What shall we do then? The fundamental problem is that we should treat kidney disease and only in this way, can we avoid the new damage in the transplanted kidney and avoid another kidney transplant. How to treat then?
As we know, most kidney diseases are caused by immune disorder. So our focus should be aimed at adjusting the unbalanced immune system, thus increasing immune ability. On the basis of this, in our Hospital, doctors and experts created immunotherapy, which is the combination of both Chinese Medicine and western medicine and can be divided into six steps: immune diagnosis, immune clearance, immune inhibition, immune tolerance, immune adjustment and immune protection.
Through immune diagnosis, we can know where the immune complex deposits exactly and the exact type of immune response so that doctors can get more scientific diagnosis and arrange better treatment. Through immune clearance, we can clear away the immune complex in the blood, which can supply a cleaner inner environment for the treatment of kidney disease. The third one is immune inhibition. There is immune complex deposit onto kidney, which leads to immune response. In this case, we use medicine which can stop the excessive immune response, thus stopping the inflammation response at a rapid speed.
After that, patients will come into immune tolerance and immune adjustment stage. In adjustment stage in particular, many effective medicines are used such as Chinese Medicine, which is used to clear away the immune complex which deposits onto kidney, which is very critical. In the last step, stem cell therapy is also applied, which is used to repair damaged intrinsic cells, differentiate into necrotic cells and increase the immune ability at the same time.
From the above, we can know that after these steps, the transplanted kidney can avoid getting damaged, thus preventing from kidney disease once more.
Kidney Transplant Life Expectancy
Patients who have developed into kidney failure stage and are under dialysis want to stop dialysis. So they consider kidney transplant, which can help get rid of dialysis and live a normal life. However, when it comes to kidney transplant, they will also consider the life expectancy of the transplanted kidney.
Experts in kidney disease field point out that different transplanted kidneys have different life expectancy. Some can accompany patients for the life time, and some can last as long as 10 to 20 years. In some cases, patients even will die in the operation room if the operation fails.
In addition to this, patients will renal failure also consider other problems such as the cost, whether a proper can be got and after kidney transplant, what medicine they will take, and so on. So many problems make patients feel headache. What’s worse, after the transplanted kidney has something wrong, they will consider another therapy. So kidney transplant is not the ultimate choice.
Is there any method which can give a solution? Absolutely. Patients should be confident that there must be one. We have Chinese Medicine and stem cell transplant, which can help revive renal function.
Firstly, renal failure patients will receive Chinese Medicine. It is mainly from Chinese herbs growing in nature, which contains nutrition and active materials and has no side effect. Micro means that compared with traditional Chinese medicine, it is finer, like powers and the use ratio is higher.
However, for those which are necrotic, we use stem cell transplant, which can differentiate into cells and replace those necrotic ones. stem cell has the following advantages.
1. Stem cell therapy can enter kidney nidus and then play roles and has no side effect.
2. Stem cell can generate capillary blood vessels and improve partial micro-circulation.
3. It can secrete a series of nutritious stimulating factors, which activates the damaged intrinsic cells and makes them recover as well as differentiate into those which can replace the necrotic ones.
4. Improve the damaged immunologic function.
We believe that as long as renal failure patients try the combination of these two therapies, they can avoid kidney transplant.
Experts in kidney disease field point out that different transplanted kidneys have different life expectancy. Some can accompany patients for the life time, and some can last as long as 10 to 20 years. In some cases, patients even will die in the operation room if the operation fails.
In addition to this, patients will renal failure also consider other problems such as the cost, whether a proper can be got and after kidney transplant, what medicine they will take, and so on. So many problems make patients feel headache. What’s worse, after the transplanted kidney has something wrong, they will consider another therapy. So kidney transplant is not the ultimate choice.
Is there any method which can give a solution? Absolutely. Patients should be confident that there must be one. We have Chinese Medicine and stem cell transplant, which can help revive renal function.
Firstly, renal failure patients will receive Chinese Medicine. It is mainly from Chinese herbs growing in nature, which contains nutrition and active materials and has no side effect. Micro means that compared with traditional Chinese medicine, it is finer, like powers and the use ratio is higher.
However, for those which are necrotic, we use stem cell transplant, which can differentiate into cells and replace those necrotic ones. stem cell has the following advantages.
1. Stem cell therapy can enter kidney nidus and then play roles and has no side effect.
2. Stem cell can generate capillary blood vessels and improve partial micro-circulation.
3. It can secrete a series of nutritious stimulating factors, which activates the damaged intrinsic cells and makes them recover as well as differentiate into those which can replace the necrotic ones.
4. Improve the damaged immunologic function.
We believe that as long as renal failure patients try the combination of these two therapies, they can avoid kidney transplant.
Effect of Renal Transplantation for Chronic Renal Disease
In the advanced stage of renal failure, kidney nearly fails to work, and patients with chronic kidney disease are suffering from many symptoms such as edema, little urine and fatigue and so on. So more and more patients decide to have renal transplantation. At the same time, they also want to know the effects of renal transplantation.
1. Kidney transplantation operation is risky. Once it is not successful, patients with chronic renal disease will die. In addition, after renal transplantation, the life span of transplanted kidney is also limited. After it fails, we should once more think of effective measures to treat chronic kidney disease.
2. Even the operation is successful, patients should still take in medicine which can prevent the rejection.
3. Renal transplantation can not treat chronic kidney disease. We should explain why kidney disease comes into being firstly. In normal condition, the recycling immune complex flows through kidney together with blood circulation, deposit on kidney, and the intrinsic immune system can discharge them out. However, when the immune system is damaged, the immune complex cannot be discharged out, so they will deposit and lead to a series of excessive immune response. We can also say that most kidney diseases are caused by immune problem. If we do not adjust the immune system, the new immune complex will come into being and deposit once more, which leads to the new deposition of immune complex onto kidney, thus causing damage in the kidney once more.
From the above, we can get a conclusion that renal transplantation has side effects. Besides this, we can try another method. Immunotherapy is strongly recommended for you, which is the combination of Chinese medicine and western medicine and can be divided into 6 steps: immune diagnosis, immune clearance, immune inhibition, immune tolerance, immune adjustment and immune protection.
1. Kidney transplantation operation is risky. Once it is not successful, patients with chronic renal disease will die. In addition, after renal transplantation, the life span of transplanted kidney is also limited. After it fails, we should once more think of effective measures to treat chronic kidney disease.
2. Even the operation is successful, patients should still take in medicine which can prevent the rejection.
3. Renal transplantation can not treat chronic kidney disease. We should explain why kidney disease comes into being firstly. In normal condition, the recycling immune complex flows through kidney together with blood circulation, deposit on kidney, and the intrinsic immune system can discharge them out. However, when the immune system is damaged, the immune complex cannot be discharged out, so they will deposit and lead to a series of excessive immune response. We can also say that most kidney diseases are caused by immune problem. If we do not adjust the immune system, the new immune complex will come into being and deposit once more, which leads to the new deposition of immune complex onto kidney, thus causing damage in the kidney once more.
From the above, we can get a conclusion that renal transplantation has side effects. Besides this, we can try another method. Immunotherapy is strongly recommended for you, which is the combination of Chinese medicine and western medicine and can be divided into 6 steps: immune diagnosis, immune clearance, immune inhibition, immune tolerance, immune adjustment and immune protection.
The Contraindication of Kidney Transplant
When patients with kidney disease develop into end stage of renal failure, they are eager to get a matched donated kidney which can help them survive for a long time. On one hand, the donated kidney is hard to find. On the other hand, even if a person volunteers to donated kidney, can the kidney disease patient receive kidney transplant? Actually, there are some contraindications of kidney transplant. Who is suitable for kidney transplant? Who is not? The questions patients often ask go as follows:
1. Can patients with primary kidney disease receive kidney transplant?
Primary kidney disease contains PKD, chronic pyelonephritis, chronic interstitial nephritis, etc. After receiving kidney transplant, such kidney diseases may recur as FSGS, IgA Nephritis, membranous nephritis, etc. These diseases can lead to the lost of renal function after transplantation. However, the rate is just less than 5%. Therefore, it can not be regarded as the contraindication of kidney transplant.
2. Can older people be suitable for kidney transplant?
As we know, kidney transplant is an operation. In most transplant center, there is no limitation in age. Whether patients can receive kidney transplant is up to patient’s physical condition.
3. Can patients with secondary kidney disease receive kidney transplant?
The effect of patients who have type 1 diabetes and have developed into renal failure is better. The treatment of selective renal failure caused by diabetes is the combination transplant of pancrease and kidney.
4. Can patients with insufficiency of heart cerebrovascular disease receive kidney transplant?
Patients with such disease can consider kidney transplant after the bypass operation. Patients with temporary cerebral ischemia can consider kidney disease 6 months later.
5. Can patients with tumor receive kidney transplant?
Generally, those with not so serious tumor can consider kidney transplant such as carcinoma in situ, carcinoma of urinary bladder. After treatment, kidney transplant can be adopted. Most patients with tumor should not receive kidney transplant until 2 two years.
From the above-mentioned, we can get a conclusion that some patients can not receive kidney transplant even they are found out to have renal failure. Is there a therapy for those who can not receive transplant? That is stem cell transplant. It is suitable for nearly all patients who have developed renal failure. What’s more, it has no contraindications or side effects. It need not any match in type, which is relatively more convenient compared with kidney transplant. In addition, it is not difficult the get in contrast to kidney transplant.
1. Can patients with primary kidney disease receive kidney transplant?
Primary kidney disease contains PKD, chronic pyelonephritis, chronic interstitial nephritis, etc. After receiving kidney transplant, such kidney diseases may recur as FSGS, IgA Nephritis, membranous nephritis, etc. These diseases can lead to the lost of renal function after transplantation. However, the rate is just less than 5%. Therefore, it can not be regarded as the contraindication of kidney transplant.
2. Can older people be suitable for kidney transplant?
As we know, kidney transplant is an operation. In most transplant center, there is no limitation in age. Whether patients can receive kidney transplant is up to patient’s physical condition.
3. Can patients with secondary kidney disease receive kidney transplant?
The effect of patients who have type 1 diabetes and have developed into renal failure is better. The treatment of selective renal failure caused by diabetes is the combination transplant of pancrease and kidney.
4. Can patients with insufficiency of heart cerebrovascular disease receive kidney transplant?
Patients with such disease can consider kidney transplant after the bypass operation. Patients with temporary cerebral ischemia can consider kidney disease 6 months later.
5. Can patients with tumor receive kidney transplant?
Generally, those with not so serious tumor can consider kidney transplant such as carcinoma in situ, carcinoma of urinary bladder. After treatment, kidney transplant can be adopted. Most patients with tumor should not receive kidney transplant until 2 two years.
From the above-mentioned, we can get a conclusion that some patients can not receive kidney transplant even they are found out to have renal failure. Is there a therapy for those who can not receive transplant? That is stem cell transplant. It is suitable for nearly all patients who have developed renal failure. What’s more, it has no contraindications or side effects. It need not any match in type, which is relatively more convenient compared with kidney transplant. In addition, it is not difficult the get in contrast to kidney transplant.
Tuesday, May 28, 2013
How to Prevent High Blood Pressure Developing into Kidney Failure?
Long time high blood pressure can make the inner pressure in the blood rise, which leads to the leaking out of protein into urine. In this case, the filtration net of kidney will be damaged, thus causing vicious circle. If it lasts for a long time, the condition will be hard to reverse. The compensation ability of kidney will increase, so patients will develop into renal failure in advance. So how to prevent high blood pressure from developing into kidney failure? The detailed instructions are as follows:
1. monitor the blood pressure
High blood pressure can begin with youngsters and those whose parents have high blood pressure. If both of the parents have high blood pressure, their child has 46% rate of getting this disease. If one parent has high blood pressure, the rate for their child of getting high blood pressure is 28.3. So it is put forward that those who are more than 35 years old should have blood pressure test in particular so as to get timely treatment.
2. control the body weight
Obesity is a main factor which leads to high blood pressure. It is reported that the rate of high blood pressure for the fat people is 4 times higher than that of those who are not fat. So controlling the body weight is also very important.
3. control blood fat
Keep the fat in blood normal. People should have less animal fat and those which is rich in cholesterol, which can lead to atherosclerosis, thus influencing kidney as well.
4. stop smoking and drinking wine and alcohol
Both smoking and drinking wine and alcohol will increase blood pressure.
5. taking exercise
Take exercise every day, which is an effective measure which can prevent the blood pressure from rising, thus preventing kidney failure eventually.
Long time high blood pressure can make the inner pressure in the blood rise, which leads to the leaking out of protein into urine. In this case, the filtration net of kidney will be damaged, thus causing vicious circle. If it lasts for a long time, the condition will be hard to reverse. The compensation ability of kidney will increase, so patients will develop into renal failure in advance. So how to prevent high blood pressure from developing into kidney failure? The detailed instructions are as follows:
1. monitor the blood pressure
High blood pressure can begin with youngsters and those whose parents have high blood pressure. If both of the parents have high blood pressure, their child has 46% rate of getting this disease. If one parent has high blood pressure, the rate for their child of getting high blood pressure is 28.3. So it is put forward that those who are more than 35 years old should have blood pressure test in particular so as to get timely treatment.
2. control the body weight
Obesity is a main factor which leads to high blood pressure. It is reported that the rate of high blood pressure for the fat people is 4 times higher than that of those who are not fat. So controlling the body weight is also very important.
3. control blood fat
Keep the fat in blood normal. People should have less animal fat and those which is rich in cholesterol, which can lead to atherosclerosis, thus influencing kidney as well.
4. stop smoking and drinking wine and alcohol
Both smoking and drinking wine and alcohol will increase blood pressure.
5. taking exercise
Take exercise every day, which is an effective measure which can prevent the blood pressure from rising, thus preventing kidney failure eventually.
How to Treat Hypertensive Nephropathy
As we mentioned in the premier passage, in renal fibrosis stage, patients with Hypertensive Nephropathy can have a variety of symptoms. To treat Hypertensive Nephropathy, we must start with stopping the renal fibrosis and declining high blood pressure. Chinese Medicine can function as extending blood vessels, anti-inflammatory, anti-coagulation, and degrading, etc.
The first one is extending blood vessels. Due to high blood pressure, the lumen of renal small arteries will become much narrower, so the perfusion to the kidney will decrease. In this case, renal fibrosis comes into being as a result of the insufficiency of blood and oxygen. The deposition of matrix becomes more and more, which invades and even takes place of the intrinsic cells in the kidney. So the physical function of kidney loose gradually. So to solve the insufficiency of blood and oxygen in the kidney should be the first step which can stop the renal fibrosis.
Firstly, Chinese Medicine can extend all levels of renal arteries, improve the partial blood circulation, increase the effective perfusion in the kidney, improve the insufficiency of blood and oxygen in the kidney, increase the partial metabolism, accelerate the repair of damaged intrinsic cells.
Secondly, Chinese Medicine can improve the obstruct of micro-circulation in digestive system. It can also relieve the edema in mucosa, which is caused by renal fibrosis. It can also promote the increase of digestive juice secretion, and improve the appetite. In this case, the condition of patients with Hypertensive Nephropathy can be improved.
Thirdly, the active materials in Chinese Medicine can also extend the blood vessels in all levels of the whole body, improve the micro-circulation in the whole body, promote the whole system’s blood circulation, thus improving the high blood pressure condition.
The second function of Chinese Medicine is that it can play as anti-inflammation. Due to high blood pressure, the intrinsic cells will be damaged, which will lead to the infiltration of inflammatory cells. Then, inflammatory mediators will be relieved, which can lead to the renal fibrosis. So if we do not diminish inflammatory reaction, renal fibrosis cannot be stopped. Chinese Medicine can inhibit the inflammatory mediators, inactivate the toxic materials, relieve the continuous damage to the kidney, and so on.
The third function of Chinese Medicine is anti-coagulation. Long time high blood pressure can lead to the barrier of micro-circulation, which leads to the insufficiency of blood and oxygen. Gradually, the activity of anti-coagulation decrease, which promotes the adhering and gathering of blood cells, so microthrombus comes into being. In turn, microthrombus can worsen the insufficiency of blood and oxygen, leading to the development of renal fibrosis.
The last function of Chinese Medicine is degrading. It is the key point to degrade the metabolism waste. It is also a key which can reflect whether the kidney disease can be reversible.
The first one is extending blood vessels. Due to high blood pressure, the lumen of renal small arteries will become much narrower, so the perfusion to the kidney will decrease. In this case, renal fibrosis comes into being as a result of the insufficiency of blood and oxygen. The deposition of matrix becomes more and more, which invades and even takes place of the intrinsic cells in the kidney. So the physical function of kidney loose gradually. So to solve the insufficiency of blood and oxygen in the kidney should be the first step which can stop the renal fibrosis.
Firstly, Chinese Medicine can extend all levels of renal arteries, improve the partial blood circulation, increase the effective perfusion in the kidney, improve the insufficiency of blood and oxygen in the kidney, increase the partial metabolism, accelerate the repair of damaged intrinsic cells.
Secondly, Chinese Medicine can improve the obstruct of micro-circulation in digestive system. It can also relieve the edema in mucosa, which is caused by renal fibrosis. It can also promote the increase of digestive juice secretion, and improve the appetite. In this case, the condition of patients with Hypertensive Nephropathy can be improved.
Thirdly, the active materials in Chinese Medicine can also extend the blood vessels in all levels of the whole body, improve the micro-circulation in the whole body, promote the whole system’s blood circulation, thus improving the high blood pressure condition.
The second function of Chinese Medicine is that it can play as anti-inflammation. Due to high blood pressure, the intrinsic cells will be damaged, which will lead to the infiltration of inflammatory cells. Then, inflammatory mediators will be relieved, which can lead to the renal fibrosis. So if we do not diminish inflammatory reaction, renal fibrosis cannot be stopped. Chinese Medicine can inhibit the inflammatory mediators, inactivate the toxic materials, relieve the continuous damage to the kidney, and so on.
The third function of Chinese Medicine is anti-coagulation. Long time high blood pressure can lead to the barrier of micro-circulation, which leads to the insufficiency of blood and oxygen. Gradually, the activity of anti-coagulation decrease, which promotes the adhering and gathering of blood cells, so microthrombus comes into being. In turn, microthrombus can worsen the insufficiency of blood and oxygen, leading to the development of renal fibrosis.
The last function of Chinese Medicine is degrading. It is the key point to degrade the metabolism waste. It is also a key which can reflect whether the kidney disease can be reversible.
The Prevention of Hypertensive Nephropathy
Hypertensive Nephropathy is a kind of benign or malignant small artery arterial sclerosis caused by long time high blood pressure. Kidney is an organ which can filtrate the toxins in the body, prevent the leak out of proteins and blood cells, etc. High blood pressure can lead to high pressure in the blood, make the protein leak out. Once the protein leaks out, the filtration net system in the kidney will also be damaged, which leads to vicious circle. In addition, long time damage can lead to the irreversible condition. So if we don’t treat Hypertensive Nephropathy timely and properly, blood vessels will be damaged, which leads to the insufficiency of blood supply, thus causing damage to the damage. The above mentioned are the process of how Hypertensive Nephropathy deteriorates. Preventing Hypertensive Nephropathy becomes more and more important and necessary.
Firstly, to prevent Hypertensive Nephropathy, we should change unhealthy or unscientific lifestyle. Keep on a diet and loose weight if necessary. For those who have more fat in the waist and extra body weight, they are more likely to suffer from high blood pressure. So they should lessen the intake of energy, do more exercise, and keep a proper body weight.
Secondly, people should keep low salt diet. If they take in too much salt, the blood vessels sclerosis will take place. WHO suggest that the daily intake of salt should be under 6g. As for those with high blood pressure, only limiting the intake of salt can make blood pressure turn normal. As for those with serious high blood pressure, limiting the intake of salt can help increase the treatment effect of hypotensor and makes the dosage of hypotensor decrease gradually.
Thirdly, people with high blood pressure should balance the intake of diet. They should reduce the intake of fat, increase the intake of fresh vegetables and fruits. In addition, have more food which is rich in calcium such as milk and beans which can help control the fat in the blood and complement the potassium and calcium.
Fourthly, patients with high blood pressure should take part in regular exercise according to the specific physical condition for enough and proper exercise can help strengthen the body and accelerate the metabolism in the body.
Last but not least, have test on the blood pressure, prevent it from being abnormal. Once blood pressure increases rapidly or people feel discomfort, go to see a doctor as soon as possible. In daily life, we should take in medicine following doctor’s advice.
Firstly, to prevent Hypertensive Nephropathy, we should change unhealthy or unscientific lifestyle. Keep on a diet and loose weight if necessary. For those who have more fat in the waist and extra body weight, they are more likely to suffer from high blood pressure. So they should lessen the intake of energy, do more exercise, and keep a proper body weight.
Secondly, people should keep low salt diet. If they take in too much salt, the blood vessels sclerosis will take place. WHO suggest that the daily intake of salt should be under 6g. As for those with high blood pressure, only limiting the intake of salt can make blood pressure turn normal. As for those with serious high blood pressure, limiting the intake of salt can help increase the treatment effect of hypotensor and makes the dosage of hypotensor decrease gradually.
Thirdly, people with high blood pressure should balance the intake of diet. They should reduce the intake of fat, increase the intake of fresh vegetables and fruits. In addition, have more food which is rich in calcium such as milk and beans which can help control the fat in the blood and complement the potassium and calcium.
Fourthly, patients with high blood pressure should take part in regular exercise according to the specific physical condition for enough and proper exercise can help strengthen the body and accelerate the metabolism in the body.
Last but not least, have test on the blood pressure, prevent it from being abnormal. Once blood pressure increases rapidly or people feel discomfort, go to see a doctor as soon as possible. In daily life, we should take in medicine following doctor’s advice.
Why do People Have Hypertensive Nephropathy
Hypertensive Nephropathy is a term in clinic, which is diagnosed by the index in clinic. In recent years, with the development of cytology, Hypertensive Nephropathy is caused by long time high blood pressure due to insufficiency of blood in renal endothelial cell.
The pathogenesis of Hypertensive Nephropathy is as follows: due to insufficiency in blood, high blood pressure causes damage in the kidney. In addition, it is also caused by the hyperfiltration and high TMP in renal glomeruli. With the continuous development of high blood pressure and the structure damage in renal arteries, the wall of tubules become thicker, which leads to the decrease of renal blood flow, thus causing insufficiency of blood and oxygen in the renal capillary endothelial cell. After the capillary endothelial cells are damaged, the activity of anticoagulation will also decrease, which promotes the gathering of blood cells and take part in the form of thrombosis. After the endothelial cells are activated, phenotype changes, which releases a series of cell factors to attract the infiltration of inflammatory cells. In this case, the filtration barrier is damaged. Protein will leak out, which leads to the start of renal fibrosis. At this time, a series of symptoms such as proteinuria, edema, increased urine at night will appear.
Hypertensive Nephropathy is a term in clinic, which is diagnosed by the index in clinic. In recent years, with the development of cytology, Hypertensive Nephropathy is caused by long time high blood pressure due to insufficiency of blood in renal endothelial cell.
The pathogenesis of Hypertensive Nephropathy is as follows: due to insufficiency in blood, high blood pressure causes damage in the kidney. In addition, it is also caused by the hyperfiltration and high TMP in renal glomeruli. With the continuous development of high blood pressure and the structure damage in renal arteries, the wall of tubules become thicker, which leads to the decrease of renal blood flow, thus causing insufficiency of blood and oxygen in the renal capillary endothelial cell. After the capillary endothelial cells are damaged, the activity of anticoagulation will also decrease, which promotes the gathering of blood cells and take part in the form of thrombosis. After the endothelial cells are activated, phenotype changes, which releases a series of cell factors to attract the infiltration of inflammatory cells. In this case, the filtration barrier is damaged. Protein will leak out, which leads to the start of renal fibrosis. At this time, a series of symptoms such as proteinuria, edema, increased urine at night will appear.
High Blood Pressure leads to Renal Failure
Renal failure which is caused by high blood pressure is called advanced stage of Hypertensive Nephropathy. In this passage, we will supply solutions of renal failure which is caused by high blood pressure. Firstly, we should look at why high blood pressure causes renal failure. The reasons go as follows:
On the basis of cytology, Hypertensive Nephropathy is a kind of kidney disorder, the damage of which is endothelial cell because of insufficiency of blood. When patients are in hypertension or high blood pressure condition, blood pressure will not keep stable, which rises or decreases suddenly. In this case, the rising and falling blood pressure will stimulate the renal glomerular capillaries, which leads the wall of the renal glomerular to suffer from more pressure. The capillary walls suffer from brushing, which leads the lumen of renal capillary to become narrower, thus causing renal insufficiency. In this condition, the renal glomerular capillaries will be damaged, which attracts the infiltration of inflammatory cells. Long time filtration will make the structure of the cells change. Then, the renal glomerular filtration function will be damaged.
Usually, patients take in hypotensor to lower the high blood pressure, so as to decrease the damage caused by it, however, it can only lower blood pressure for the time being and patients also have realized its side effects. So they are seeking a new medicine.
In this passage, we will introduce you a new therapy, which is called Chinese Medicine. High blood pressure firstly leads to insufficiency of blood and oxygen in the micro-blood vessels and even the sclerosis of micro-blood vessels. So Chinese Medicine firstly is aimed at solving it. In Chinese Medicine, there are active Chinese herbs which can improve the blood circulation, especially the micro-circulation. In this case, sclerosis will not take place, thus relieving high blood pressure.
Chinese Medicine is advanced than traditional Chinese medicine compared with the style of application. The mechanism of it is extending blood vessels, anticoagulation, anti-inflammation, and degradation. In addition, the active materials in Chinese Medicine can improve the permeability of renal glomerular filtration, control the leak out of protein, improve the disorder adjustment of renal blood vessels, improve the renal glomerular filtration, improve the insufficiency of blood and oxygen in the kidney, which blocks the renal glomerular sclerosis and the fibrosis of renal tubules and renal mesangial area, thus declining the blood pressure and reviving renal functions fundamentally.
On the basis of cytology, Hypertensive Nephropathy is a kind of kidney disorder, the damage of which is endothelial cell because of insufficiency of blood. When patients are in hypertension or high blood pressure condition, blood pressure will not keep stable, which rises or decreases suddenly. In this case, the rising and falling blood pressure will stimulate the renal glomerular capillaries, which leads the wall of the renal glomerular to suffer from more pressure. The capillary walls suffer from brushing, which leads the lumen of renal capillary to become narrower, thus causing renal insufficiency. In this condition, the renal glomerular capillaries will be damaged, which attracts the infiltration of inflammatory cells. Long time filtration will make the structure of the cells change. Then, the renal glomerular filtration function will be damaged.
Usually, patients take in hypotensor to lower the high blood pressure, so as to decrease the damage caused by it, however, it can only lower blood pressure for the time being and patients also have realized its side effects. So they are seeking a new medicine.
In this passage, we will introduce you a new therapy, which is called Chinese Medicine. High blood pressure firstly leads to insufficiency of blood and oxygen in the micro-blood vessels and even the sclerosis of micro-blood vessels. So Chinese Medicine firstly is aimed at solving it. In Chinese Medicine, there are active Chinese herbs which can improve the blood circulation, especially the micro-circulation. In this case, sclerosis will not take place, thus relieving high blood pressure.
Chinese Medicine is advanced than traditional Chinese medicine compared with the style of application. The mechanism of it is extending blood vessels, anticoagulation, anti-inflammation, and degradation. In addition, the active materials in Chinese Medicine can improve the permeability of renal glomerular filtration, control the leak out of protein, improve the disorder adjustment of renal blood vessels, improve the renal glomerular filtration, improve the insufficiency of blood and oxygen in the kidney, which blocks the renal glomerular sclerosis and the fibrosis of renal tubules and renal mesangial area, thus declining the blood pressure and reviving renal functions fundamentally.
High Blood Pressure and Kidney Disease Interact
It is said by experts that at present there are more than 90 million people in China who are suffering from kidney disease, 30% of whom are caused by high blood pressure. In addition, there are more and more young people who are suffering from high blood pressure. So we can also say, high blood pressure and kidney disease is a pair of partner, which interact each other and even lead to a vicious circle.
In normal condition, 19% of blood in afferent arterioles is filtrated into renal tubules by renal glomeruli, thus forming original urine. 99% of original urine can be reabsorped by renal tubules into blood circulation, which can maintain the balance of body infusion. In this way, the waste things are discharged, and the blood content is also maintained balanced relatively. Once there is lesion in the kidney, the blood circulation will be blocked, and the blood flow in the kidney will decrease, which can activate some factors which can increase the blood pressure in the body such as renin and so on. These factors can lead to the whole arteriolospasm and increased resistance of arteriole, thus causing increased high blood pressure.
In addition, once kidney is damaged, it can not discharge out the sodium and water, which leads to the retention of water and sodium, thus increasing the blood content and increased high blood pressure. In a world, kidney plays an important role in adjusting the metabolism of water and sodium and in secreting materials which can activate the blood vessels. Materials which can increase the retention of water and sodium increase, and those which can lead the blood vessels to shrink decrease, so the rate of high blood pressure increase accordingly.
What’s more, kidney is also a main organ which is influenced by high blood pressure. Long time high blood pressure can lead the inner pressure in the capsule of renal glomeruli to increase, cause fibrosis of renal glomeruli, which will finally develop into renal failure. At present, in the treatment of high blood pressure, there are some wrong ways.
Firstly, when people have high blood pressure, they go to hospital but only test whether the heart functions well. They do not go to have a test of renal function such as urine test and blood test. So the damage of kidney is usually ignored.
In normal condition, 19% of blood in afferent arterioles is filtrated into renal tubules by renal glomeruli, thus forming original urine. 99% of original urine can be reabsorped by renal tubules into blood circulation, which can maintain the balance of body infusion. In this way, the waste things are discharged, and the blood content is also maintained balanced relatively. Once there is lesion in the kidney, the blood circulation will be blocked, and the blood flow in the kidney will decrease, which can activate some factors which can increase the blood pressure in the body such as renin and so on. These factors can lead to the whole arteriolospasm and increased resistance of arteriole, thus causing increased high blood pressure.
In addition, once kidney is damaged, it can not discharge out the sodium and water, which leads to the retention of water and sodium, thus increasing the blood content and increased high blood pressure. In a world, kidney plays an important role in adjusting the metabolism of water and sodium and in secreting materials which can activate the blood vessels. Materials which can increase the retention of water and sodium increase, and those which can lead the blood vessels to shrink decrease, so the rate of high blood pressure increase accordingly.
What’s more, kidney is also a main organ which is influenced by high blood pressure. Long time high blood pressure can lead the inner pressure in the capsule of renal glomeruli to increase, cause fibrosis of renal glomeruli, which will finally develop into renal failure. At present, in the treatment of high blood pressure, there are some wrong ways.
Firstly, when people have high blood pressure, they go to hospital but only test whether the heart functions well. They do not go to have a test of renal function such as urine test and blood test. So the damage of kidney is usually ignored.
Sunday, May 26, 2013
CKD (Chronic Kidney Disease) and Its Clinical Stages
The definition of CKD( chronic kidney disease) is that is a person has more than 3 months symptoms such as proteinuria, hematuria, with or without decreased GFR( glomerualr filtration function), he will be diagnosed with CKD( chronic kidney disease).From this definition, we can find out that besides acute renal nephritis and acute urinary tract infection, most kidney diseases can be called CKD( chronic kidney disease). In China, doctors all follow the following criteria to get a conclusion how serious the patient’s condition is.
The first stage of CKD( chronic kidney disease) is compensation stage of renal insufficiency. In this stage, the damdaged renal units are not more than 50%. Serum creatinine is still in normal range for kidney has a strong ability of compensation. The serum creatinine is 50～80ml/min. Besides increased enuresis nocturna, there is no other clinical symptoms.
The second stage of CKD( chronic kidney disease) is discompensation stage of renal insufficiency. The damdaged renal units rose to more than 50%. The serum creatinine is 50～20ml/min. Serum creatinine is 133～442μmol/L. BUN(blood urea nitrogen) rose to more than 7.1mm01/L. Patients in this stage can feel weakness, and a little anemia, and so on.
The third stage of CKD( chronic kidney disease) is renal failure stage. In this stage, serum creatinine increased to 442～707μmol/L and the serum creatinine decreased to 20～10ml/min. BUN(blood urea nitrogen) rose to more than 179～286mmol/L. Patients with CKD( chronic kidney disease)have anemia, acid base disturbance, electrolyte disturbance and so on.
The end stage of CKD( chronic kidney disease) is uremia. In this stage, the serum creatinine is more than 707μmol/L. The creatinine clearance decreased to below 10ml/min. BUN(blood urea nitrogen)is more than 286mmol/L. patients have obvious acidosis, anemia and serious systematic symptoms.
In China, most people do not have physical examination every year. So, when they can feel the symptoms such as pain in the back, protein in urine, red blood cells in urine, the damage has been serious. What’s worse, some may even be diagnosed with uremia and receive dialysis directly for kidney has strong ability of compensation, which is scary and should have been attached importance to. Late treatment also has difficult in treating CKD( chronic kidney disease) well and the effect may be not so satisfactory. So to assure the effect, people should have physical examination every year because the earlier, the better.
The first stage of CKD( chronic kidney disease) is compensation stage of renal insufficiency. In this stage, the damdaged renal units are not more than 50%. Serum creatinine is still in normal range for kidney has a strong ability of compensation. The serum creatinine is 50～80ml/min. Besides increased enuresis nocturna, there is no other clinical symptoms.
The second stage of CKD( chronic kidney disease) is discompensation stage of renal insufficiency. The damdaged renal units rose to more than 50%. The serum creatinine is 50～20ml/min. Serum creatinine is 133～442μmol/L. BUN(blood urea nitrogen) rose to more than 7.1mm01/L. Patients in this stage can feel weakness, and a little anemia, and so on.
The third stage of CKD( chronic kidney disease) is renal failure stage. In this stage, serum creatinine increased to 442～707μmol/L and the serum creatinine decreased to 20～10ml/min. BUN(blood urea nitrogen) rose to more than 179～286mmol/L. Patients with CKD( chronic kidney disease)have anemia, acid base disturbance, electrolyte disturbance and so on.
The end stage of CKD( chronic kidney disease) is uremia. In this stage, the serum creatinine is more than 707μmol/L. The creatinine clearance decreased to below 10ml/min. BUN(blood urea nitrogen)is more than 286mmol/L. patients have obvious acidosis, anemia and serious systematic symptoms.
In China, most people do not have physical examination every year. So, when they can feel the symptoms such as pain in the back, protein in urine, red blood cells in urine, the damage has been serious. What’s worse, some may even be diagnosed with uremia and receive dialysis directly for kidney has strong ability of compensation, which is scary and should have been attached importance to. Late treatment also has difficult in treating CKD( chronic kidney disease) well and the effect may be not so satisfactory. So to assure the effect, people should have physical examination every year because the earlier, the better.
Does CKD Stage 3 Mean Dialysis
I am diagnosed with CKD stage 3. I am from Florida, America. My serum creatinine is 442umol/l. My doctor told me that I am in the edge of dialysis for in my local hospital, when serum creatinine rises up to 445 umol/l, we will be reminded to take dialysis. Anyhow, I don’t want to take dialysis for after I surf the Internet, I find out some side effects and complications of dialysis, which makes me seek for alternative methods. Does CKD stage 3 surely mean dialysis?
Sir, please do not worry. CKD stage 3 as your condition needn’t take dialysis and we can supply an alternative method Micro-Chinese Medicine Osmotherapy. I will present one by one.
Firstly, just as you say, when serum creatinine rises up to 445 umol/l, kidney disease patients in most of countries will be suggested by their doctor to take dialysis. In this condition, kidney falls into discompensation stage, which means renal glmerulus which replace the filtration work of other damaged renal glmerulus fall ill as well. On the other hand, creatinine is accumulated into the blood, which should have been discharged out of the body. That is because creatinine is toxic small molecules which results from metabolism of muscles. If excessive amount of creatinine accumulates in blood for a long time, it will damage the body. So we are suggested to take dialysis.
Secondly, as you say, long time dialysis can lead to some side effects and complications of dialysis, which also can not repair the damaged intrinsic cells in the kidney, thus preventing the further damage to the healthy cells at present.
Last but not least, we recommend you Chinese Medicine, which can help stage 3 CKD patients far from dialysis. The mechanism goes as follows: the leaking out of the creatinine from serum into urine is because of the damaged intrinsic cells in the kidney. In normal condition, creatinine is small molecule which can pass through renal glomerular filtration membrane. When the renal glomerular filtration membrane is damaged, they can not pass as usual, which leads to high creatinine in serum. After Chinese Medicine is applied into patients’ body, it will extend blood vessels, especially the micro-blood vessels, improve the blood circulation, especially the micro-blood circulation, which lay foundation for the treatment. After that, a cleaner inner environment will be created. Then, the active materials in Chinese Medicine will play role and repair the damaged intrinsic cells in the kidney such as renal glomerular filtration membrane, thus rebuilding renal structure and reviving renal function. At last, excessive toxic small molecules such as creatinine will also be discharged out of the body and keep the inner environment clean.
So from the above, we can know that stage 3 patients can avoid dialysis with the help of Chinese Medicine.
I am diagnosed with CKD stage 3. I am from Florida, America. My serum creatinine is 442umol/l. My doctor told me that I am in the edge of dialysis for in my local hospital, when serum creatinine rises up to 445 umol/l, we will be reminded to take dialysis. Anyhow, I don’t want to take dialysis for after I surf the Internet, I find out some side effects and complications of dialysis, which makes me seek for alternative methods. Does CKD stage 3 surely mean dialysis?
Sir, please do not worry. CKD stage 3 as your condition needn’t take dialysis and we can supply an alternative method Micro-Chinese Medicine Osmotherapy. I will present one by one.
Firstly, just as you say, when serum creatinine rises up to 445 umol/l, kidney disease patients in most of countries will be suggested by their doctor to take dialysis. In this condition, kidney falls into discompensation stage, which means renal glmerulus which replace the filtration work of other damaged renal glmerulus fall ill as well. On the other hand, creatinine is accumulated into the blood, which should have been discharged out of the body. That is because creatinine is toxic small molecules which results from metabolism of muscles. If excessive amount of creatinine accumulates in blood for a long time, it will damage the body. So we are suggested to take dialysis.
Secondly, as you say, long time dialysis can lead to some side effects and complications of dialysis, which also can not repair the damaged intrinsic cells in the kidney, thus preventing the further damage to the healthy cells at present.
Last but not least, we recommend you Chinese Medicine, which can help stage 3 CKD patients far from dialysis. The mechanism goes as follows: the leaking out of the creatinine from serum into urine is because of the damaged intrinsic cells in the kidney. In normal condition, creatinine is small molecule which can pass through renal glomerular filtration membrane. When the renal glomerular filtration membrane is damaged, they can not pass as usual, which leads to high creatinine in serum. After Chinese Medicine is applied into patients’ body, it will extend blood vessels, especially the micro-blood vessels, improve the blood circulation, especially the micro-blood circulation, which lay foundation for the treatment. After that, a cleaner inner environment will be created. Then, the active materials in Chinese Medicine will play role and repair the damaged intrinsic cells in the kidney such as renal glomerular filtration membrane, thus rebuilding renal structure and reviving renal function. At last, excessive toxic small molecules such as creatinine will also be discharged out of the body and keep the inner environment clean.
So from the above, we can know that stage 3 patients can avoid dialysis with the help of Chinese Medicine.
Stage 3 Kidney Disease Life Expectancy
Internationally, doctors judge the damage degree of kidney disease by GFR( glomerular filtration rate) besides serum creatine. According to GFR( glomerular filtration rate), CKD(Chronic Kidney Disease) can be divided into five stages. The normal range of GFR( glomerular filtration rate) is 80 to 120 ml/(min•1.73㎡), which shows the volumn of blood which flows into kidney per minute. GFR is a very scientific index which indicates how kidney is damaged and in other words, it shows how the renal function is.
In the first stage, GFR is normal or high, which is more than 90 ml/(min•1.73㎡). Patients may have no symptoms because of the strong ability of compensation of the kidney.
In the second stage, GFR declines to 60～90ml/(min•1.73㎡). In the third stage, GFR declines to 30～59ml/(min•1.73㎡). Patients fall into renal failure stage based on Chinese traditional standard. The serum creatinine rises to 442 to 707μmol/L(5～8mg/dl). The creatinine clearance rate declines to 20 to 10 ml/min. BUN ( blood urea nitrogen) increased to 179～286mmol/L(50～80mg/dl).
In the fourth stage, GFR declines to 15 to 29 ml/(min•1.73㎡). The fifth stage of CKD is that GFR declines to less than ml/(min•1.73㎡). We can also say that patients develop into uremia stage. They can suffer from symptoms in nerve system, digestive system, blood system, and so on.
Patients with CKD (Chronic Kidney Disease) Stage 3 can also have some symptoms. They will suffer from anemia, balance disorders of water, electrolyte and acid-base. Suffering from these, patients with CKD(Chronic Kidney Disease) Stage 3 even loose confidence.
So patients with CKD (Chronic Kidney Disease) Stage 3 want to know life expectancy. How long will I live? Is the future fearful really? Absolutely not. Experts in kidney disease field point out that in most time, patients with CKD(Chronic Kidney Disease) Stage 3 can not receive scientific treatment and the medicine just focus on the symptoms such as hormone, immunosuppressive agent. They focus on dimishing the symptoms and once patients with CKD (Chronic Kidney Disease) Stage 3 have got an infection such as cold, symptoms will recur again. What’s worse, it makes patients depressed and even hopeless. But do not worry because there is also a new therapy which maybe you have not heard of it before but it really can bring you new hope.
Chinese Medicine can promote the blood circulation and dissolve the stasis in the blood, creating a clearer inner environment. Secondly, Chinese Medicine contains many active and nutritious substances, which can repair the damaged intrinsic cells and prevent proteins and red blood cells, etc from leaking out fundamentally. After more than one months’ treatment in hospital, patients with CKD (Chronic Kidney Disease) Stage 3 should apply Chinese Medicine for another more than 3 months to consolidate the effect. So the total treatment may take 4 months.
So there is no need to worry. In stage 3, the damage in kidney is not so serious. In other words, it can be treated well as long as the treatment is effective and timely.
If you still have any other questions about Chinese Medicine, please feel free to consult the experts online or email us.
In the first stage, GFR is normal or high, which is more than 90 ml/(min•1.73㎡). Patients may have no symptoms because of the strong ability of compensation of the kidney.
In the second stage, GFR declines to 60～90ml/(min•1.73㎡). In the third stage, GFR declines to 30～59ml/(min•1.73㎡). Patients fall into renal failure stage based on Chinese traditional standard. The serum creatinine rises to 442 to 707μmol/L(5～8mg/dl). The creatinine clearance rate declines to 20 to 10 ml/min. BUN ( blood urea nitrogen) increased to 179～286mmol/L(50～80mg/dl).
In the fourth stage, GFR declines to 15 to 29 ml/(min•1.73㎡). The fifth stage of CKD is that GFR declines to less than ml/(min•1.73㎡). We can also say that patients develop into uremia stage. They can suffer from symptoms in nerve system, digestive system, blood system, and so on.
Patients with CKD (Chronic Kidney Disease) Stage 3 can also have some symptoms. They will suffer from anemia, balance disorders of water, electrolyte and acid-base. Suffering from these, patients with CKD(Chronic Kidney Disease) Stage 3 even loose confidence.
So patients with CKD (Chronic Kidney Disease) Stage 3 want to know life expectancy. How long will I live? Is the future fearful really? Absolutely not. Experts in kidney disease field point out that in most time, patients with CKD(Chronic Kidney Disease) Stage 3 can not receive scientific treatment and the medicine just focus on the symptoms such as hormone, immunosuppressive agent. They focus on dimishing the symptoms and once patients with CKD (Chronic Kidney Disease) Stage 3 have got an infection such as cold, symptoms will recur again. What’s worse, it makes patients depressed and even hopeless. But do not worry because there is also a new therapy which maybe you have not heard of it before but it really can bring you new hope.
Chinese Medicine can promote the blood circulation and dissolve the stasis in the blood, creating a clearer inner environment. Secondly, Chinese Medicine contains many active and nutritious substances, which can repair the damaged intrinsic cells and prevent proteins and red blood cells, etc from leaking out fundamentally. After more than one months’ treatment in hospital, patients with CKD (Chronic Kidney Disease) Stage 3 should apply Chinese Medicine for another more than 3 months to consolidate the effect. So the total treatment may take 4 months.
So there is no need to worry. In stage 3, the damage in kidney is not so serious. In other words, it can be treated well as long as the treatment is effective and timely.
If you still have any other questions about Chinese Medicine, please feel free to consult the experts online or email us.
Saturday, May 25, 2013
CKD Stage 2 Is the Best Time for the Treatment
According to GFR, chronic kidney disease can be divided into 5 stages. In stage2, GFR(glomerular filtration rate)declines to 60-89 ml/min. The normal range is 80 to 120 ml/min. Younger men has higher GFR than old people. Serum creatinine is 133-177umol/L. The normal range is 44 to 103 umol/L.
In the early stage of chronic kidney disease especially stage 1 and stage 2, there is nearly no symptom in clinic for kidney has a strong compensation ability. In China, some people think kidney is dumb. People usually do not pay attention to it. However, once serum creatinine rises, it indicates that the damage in the kidney is more than half. If we do not treat it timely, kidney will become atrophic for there are damaged intrinsic cells in the kidney. Of course, the earlier, the better.
Here, we’d like to introduce several methods to help discover chronic kidney disease early.
1. Test urine twice a year. If there is something wrong in the kidney, serum creatinine, urea acid will rise. Blood or protein will appear in urine when the renal glomerular membrane is damaged.
2. People with PKD, high blood pressure, diabetes or whose parents have such diseases should beware for they are hereditary.
3. In stage 2 of chronic kidney disease, people may have a little pain in back, feel fatigue and increased urine at night.
If we have found that we have come into stage 2, we should treat it timely and effectively. In our Hospital, we have immunotherapy for most kidney diseases are caused by immune problem. Immunotherapy can be divided into 6 steps such as immune diagnosis, immune clearance, immune inhibition, immune tolerance, immune adjustment and immune protection. In this passage, we mainly introduce the immune adjustment and immune protection, which are the core treatment in our kidney disease hospital.
After immune diagnose and immune clearance, we can exactly know the type of kidney disease, the amount of the immune complex and the area of immune complex and clear away the toxins in the blood, including immune complex.
Then, Chinese Medicine is applied. Chinese Medicine is a natural herbal therapy applied externally on acupoint of lower back. Herbal bags containing dozens of herbal medicines are soaked previously in penetrants, and then placed on the lower back part. With the help of osmosis device, effective ingredients of herbal medicines will infiltrate into kidneys through the main channels. After the application of Chinese Medicine, people with kidney failure may sweat in the center of palm and feet, which indicates that the micro-circulation is improved.In detail, it can repair the damaged intrinsic cells after it is into the body for it contains natural herbs and active substances.
At last, stem cell is applied if there are too many damaged cells and even some necrotic cell in stage 2 chronic kidney disease for stem cell can not only repair but also differentiate. Stem cell is especially good for diseases such as lupus nephritis, purpura nephritis,etc.
In the early stage of chronic kidney disease especially stage 1 and stage 2, there is nearly no symptom in clinic for kidney has a strong compensation ability. In China, some people think kidney is dumb. People usually do not pay attention to it. However, once serum creatinine rises, it indicates that the damage in the kidney is more than half. If we do not treat it timely, kidney will become atrophic for there are damaged intrinsic cells in the kidney. Of course, the earlier, the better.
Here, we’d like to introduce several methods to help discover chronic kidney disease early.
1. Test urine twice a year. If there is something wrong in the kidney, serum creatinine, urea acid will rise. Blood or protein will appear in urine when the renal glomerular membrane is damaged.
2. People with PKD, high blood pressure, diabetes or whose parents have such diseases should beware for they are hereditary.
3. In stage 2 of chronic kidney disease, people may have a little pain in back, feel fatigue and increased urine at night.
If we have found that we have come into stage 2, we should treat it timely and effectively. In our Hospital, we have immunotherapy for most kidney diseases are caused by immune problem. Immunotherapy can be divided into 6 steps such as immune diagnosis, immune clearance, immune inhibition, immune tolerance, immune adjustment and immune protection. In this passage, we mainly introduce the immune adjustment and immune protection, which are the core treatment in our kidney disease hospital.
After immune diagnose and immune clearance, we can exactly know the type of kidney disease, the amount of the immune complex and the area of immune complex and clear away the toxins in the blood, including immune complex.
Then, Chinese Medicine is applied. Chinese Medicine is a natural herbal therapy applied externally on acupoint of lower back. Herbal bags containing dozens of herbal medicines are soaked previously in penetrants, and then placed on the lower back part. With the help of osmosis device, effective ingredients of herbal medicines will infiltrate into kidneys through the main channels. After the application of Chinese Medicine, people with kidney failure may sweat in the center of palm and feet, which indicates that the micro-circulation is improved.In detail, it can repair the damaged intrinsic cells after it is into the body for it contains natural herbs and active substances.
At last, stem cell is applied if there are too many damaged cells and even some necrotic cell in stage 2 chronic kidney disease for stem cell can not only repair but also differentiate. Stem cell is especially good for diseases such as lupus nephritis, purpura nephritis,etc.
Management of chronic kidney disease stage 2
Stage 2 chronic kidney disease is easy to recover for kidney is still in compensation stage. As long as we take effective treatment measures and have a good management to assist the treatment, the effect will be good. How to manage? It goes as follows:
1. Do blood test and urine test to monitor the protein in urine, serum creatinine level, etc. In addition, ECT test is also necessary which can tell us the GFR, which reflects how kidney functions and is short for glomerular filtration rate.
2. Keep a healthy diet is also necessary.
§ Limit intake of refined and processed foods high in sugar and sodium
§ Choose and prepare foods with less salt or high sodium ingredients
§ Keep protein intake within the Daily Reference Intake (DRI) level recommended for healthy people
§ Consum the DRI for vitamins and minerals
§ Potassium and phosphorus are usually not restricted unless blood levels are above normal
3. Keep stage 2 chronic kidney disease patients’ blood pressure at a healthy level
a) 125/75 for those with diabetes
b) 130/85 for non-diabetes and non-proteinuria
c) 125/75 for non-diabetes with proteinuria
4. Stop drinking alcohol and smoking. Long time drinking wine or alcohol can lead to anemia, and the disorder of blood cells. Kinds of bleeding are due to the bad absorption of stomach and guts, which also lead to low use ratio of vitamin. In addition, the increased discharge of vitamin can lead to hyperlipidaemia.
5. Stop coffee. Long time drinking coffee can make patients with stage 2 kidney disease have kidney stone, which can increase the burden of the kidney. The elements in coffee can increase the amount of calcium in the urine, which is the main reason why patients have kidney stone.
1. Do blood test and urine test to monitor the protein in urine, serum creatinine level, etc. In addition, ECT test is also necessary which can tell us the GFR, which reflects how kidney functions and is short for glomerular filtration rate.
2. Keep a healthy diet is also necessary.
§ Limit intake of refined and processed foods high in sugar and sodium
§ Choose and prepare foods with less salt or high sodium ingredients
§ Keep protein intake within the Daily Reference Intake (DRI) level recommended for healthy people
§ Consum the DRI for vitamins and minerals
§ Potassium and phosphorus are usually not restricted unless blood levels are above normal
3. Keep stage 2 chronic kidney disease patients’ blood pressure at a healthy level
a) 125/75 for those with diabetes
b) 130/85 for non-diabetes and non-proteinuria
c) 125/75 for non-diabetes with proteinuria
4. Stop drinking alcohol and smoking. Long time drinking wine or alcohol can lead to anemia, and the disorder of blood cells. Kinds of bleeding are due to the bad absorption of stomach and guts, which also lead to low use ratio of vitamin. In addition, the increased discharge of vitamin can lead to hyperlipidaemia.
5. Stop coffee. Long time drinking coffee can make patients with stage 2 kidney disease have kidney stone, which can increase the burden of the kidney. The elements in coffee can increase the amount of calcium in the urine, which is the main reason why patients have kidney stone.
Stage 4 Kidney Disease, GFR 24
My husband has a GFR of 24, he is at Stage 4 kidney disease. He has FSGS, he is now starting to experience some symptoms such as the chills, weight loss, bad mouth taste and odor and some heartburn and loose bowels. The nephrologist says he will need a transplant in a few years. He is only 42 years old. He is on Coreg, ProCardia, Avapro, Torsemide, Uloric, and Lipitor. Are all these symptoms part of the renal failure and do you agree that he will need a transplant soon?
This is one of my patients’ concern. My answer is as follows:
Dear sir, please do not worry. I will explain it for you in detail.
Firstly, kidney transplant can really solve the kidney disease problem for the time being. However, if we have another choice, we should consider for kidney transplant has many advantages. 1. The donated kidney is hard to find and even if we had a donated kidney, we should consider whether it matches the patients who are ready to take kidney transplant. 2. Kidney transplant has risk, which is known to all of us. 3. The life expectancy of transplanted kidney is also limited. Some years later, the transplanted kidney will also fail to work and we should find another kidney or another therapy.
Secondly, considering the effects of kidney transplantation, we would like to introduce a new therapy: immunotherapy, which is on the basis that FSGS is caused by immune disorder.
When FSGS patients are in stage 4 and GFR has decreased to 24, we still have hope to recover. In immunotherapy, the first treatment step is immune clearance, through which, a lot of immune complex is cleared away. The methods are such as blood dialysis, blood filtration, plasma exchange, etc. The second treatment step is immune adjustment and immune protection, in which, we have both Chinese medicine and western medicine. For example, Chinese Medicine can help create a clean environment, repair the damaged intrinsic cells at the same time. In addition, stem cell is applied, which can differentiate into intrinsic cells and rebuild renal structure.
This is one of my patients’ concern. My answer is as follows:
Dear sir, please do not worry. I will explain it for you in detail.
Firstly, kidney transplant can really solve the kidney disease problem for the time being. However, if we have another choice, we should consider for kidney transplant has many advantages. 1. The donated kidney is hard to find and even if we had a donated kidney, we should consider whether it matches the patients who are ready to take kidney transplant. 2. Kidney transplant has risk, which is known to all of us. 3. The life expectancy of transplanted kidney is also limited. Some years later, the transplanted kidney will also fail to work and we should find another kidney or another therapy.
Secondly, considering the effects of kidney transplantation, we would like to introduce a new therapy: immunotherapy, which is on the basis that FSGS is caused by immune disorder.
When FSGS patients are in stage 4 and GFR has decreased to 24, we still have hope to recover. In immunotherapy, the first treatment step is immune clearance, through which, a lot of immune complex is cleared away. The methods are such as blood dialysis, blood filtration, plasma exchange, etc. The second treatment step is immune adjustment and immune protection, in which, we have both Chinese medicine and western medicine. For example, Chinese Medicine can help create a clean environment, repair the damaged intrinsic cells at the same time. In addition, stem cell is applied, which can differentiate into intrinsic cells and rebuild renal structure.
Can I Live Long with CKD Stage 3
Half a year ago, I was diagnosed with CKD stage 3. Then, I took treatment in local hospital. The medicine I use was such as prednisone, immunosuppressive agent and so on. The treatment at that time was successful. My serum creatinine decreased from 300 to 235umol/L. I could not feel any discomfort. However, recently, after a flu and fatigue from work, I had protein in urine, which makes me scared. I am concerned whether chronic kidney disease can be treated well and how long can I live?
Dear sir, firstly, please do not worry. From what you describe, after the treatment, kidney disease recurs, which leads to your anxiety. What I want to say first is that as long as we receive proper treatment, kidney disease will not recur.
Secondly, I would like to recommend you an effective therapy: immunotherapy in our Hospital. As we mentioned in the previous articles, most kidney diseases are caused by immune problem. Immunotherapy can adjust the immune system and help chronic kidney disease stage 3 patients recover fundamentally. In stage 3, the GFR decreased obviously, and there has been more immune complex deposition on the kidney for the excessive immune reaction has happened about at least several months ago.
In this case, firstly, before immune adjustment, we should have an immune diagnosis, in which case, we can figure out where exactly the immune complex deposits and the accurate amount of it, which supplies valuable evidence for the treatment of the doctors. Next, chronic kidney disease patients stage 3 will receive immune clearance, which can help clear away the immune complex in the blood and create a good treatment environment for the immunotherapy.
When stage 3 chronic kidney disease patients come to immune adjustment stage, many Chinese medicine and western medicine are applied such as Chinese Medicine and stem cell therapy. It is more advanced that the immune therapy in western medicine for it can repair the damaged intrinsic cells, differentiate into those which have been necrotic, rebuild renal function and increase the immune ability, thus treating stage 3 chronic kidney disease fundamentally.
Dear sir, firstly, please do not worry. From what you describe, after the treatment, kidney disease recurs, which leads to your anxiety. What I want to say first is that as long as we receive proper treatment, kidney disease will not recur.
Secondly, I would like to recommend you an effective therapy: immunotherapy in our Hospital. As we mentioned in the previous articles, most kidney diseases are caused by immune problem. Immunotherapy can adjust the immune system and help chronic kidney disease stage 3 patients recover fundamentally. In stage 3, the GFR decreased obviously, and there has been more immune complex deposition on the kidney for the excessive immune reaction has happened about at least several months ago.
In this case, firstly, before immune adjustment, we should have an immune diagnosis, in which case, we can figure out where exactly the immune complex deposits and the accurate amount of it, which supplies valuable evidence for the treatment of the doctors. Next, chronic kidney disease patients stage 3 will receive immune clearance, which can help clear away the immune complex in the blood and create a good treatment environment for the immunotherapy.
When stage 3 chronic kidney disease patients come to immune adjustment stage, many Chinese medicine and western medicine are applied such as Chinese Medicine and stem cell therapy. It is more advanced that the immune therapy in western medicine for it can repair the damaged intrinsic cells, differentiate into those which have been necrotic, rebuild renal function and increase the immune ability, thus treating stage 3 chronic kidney disease fundamentally.
Friday, May 24, 2013
Living with Lupus Kidney Disease
I am living with Lupus Kidney Disease. What effective therapeutic measures should we take? I am in hormone, but some doctors say that it has side effects. My protein in urine is ++.
Just as you say, in many countries, hormone is widely applied to treat Lupus Kidney Disease, which is also accompanied by immunosuppressive agent. However, they can just make the symptoms disappear for the time being, which is not complete and systematic.
Lupus Nephritis (Lupus Kidney Disease) is an autoimmune kidney damage, which is caused by the deposition of immune complex in the kidney. The pathological lesion is mainly in renal glomerular disease, which is also often seen in renal tubules and renal mesenchyme. Patients with Lupus Nephritis have red blood cells, white blood cells and protein in urine.
On the basis of the above, specialists created immunotherapy, which is systematic based on the mechanism of Lupus Kidney Disease. It is generally divided into six steps: immune diagnosis, immune clearance, immune inhibit, immune tolerance, immune adjustment and immune protection. Immune diagnosis can help us diagnose how much amount of the immune complex, which can supply clue and evidence for the treatment schedule of doctors in clinic.
In immune clearance, blood purifications are applied, especially plasma exchange, which can effectively clear away the immune complex which exists in the blood, thus reducing damage to the cells and reliving the symptoms such as hematuria and proteinuria and so on. However, as we mentioned, there is still immune complex which deposits on the kidney. What shall we do to clear it away?
In immune adjustment, Chinese Medicine and other medicine which can also benefit Qi (Chinese medical term) and nourish blood, which can also help clear away the immune complex which deposits on to the kidney, thus treating kidney disease fundamentally. Last but not least, such Chinese medicine can also increase the immunity of patients with kidney disease, which can prevent the recurrence of kidney disease from root.
Just as you say, in many countries, hormone is widely applied to treat Lupus Kidney Disease, which is also accompanied by immunosuppressive agent. However, they can just make the symptoms disappear for the time being, which is not complete and systematic.
Lupus Nephritis (Lupus Kidney Disease) is an autoimmune kidney damage, which is caused by the deposition of immune complex in the kidney. The pathological lesion is mainly in renal glomerular disease, which is also often seen in renal tubules and renal mesenchyme. Patients with Lupus Nephritis have red blood cells, white blood cells and protein in urine.
On the basis of the above, specialists created immunotherapy, which is systematic based on the mechanism of Lupus Kidney Disease. It is generally divided into six steps: immune diagnosis, immune clearance, immune inhibit, immune tolerance, immune adjustment and immune protection. Immune diagnosis can help us diagnose how much amount of the immune complex, which can supply clue and evidence for the treatment schedule of doctors in clinic.
In immune clearance, blood purifications are applied, especially plasma exchange, which can effectively clear away the immune complex which exists in the blood, thus reducing damage to the cells and reliving the symptoms such as hematuria and proteinuria and so on. However, as we mentioned, there is still immune complex which deposits on the kidney. What shall we do to clear it away?
In immune adjustment, Chinese Medicine and other medicine which can also benefit Qi (Chinese medical term) and nourish blood, which can also help clear away the immune complex which deposits on to the kidney, thus treating kidney disease fundamentally. Last but not least, such Chinese medicine can also increase the immunity of patients with kidney disease, which can prevent the recurrence of kidney disease from root.
Why People Get Lupus Nephritis
The reasons why people get Lupus Nephritis go as follows generally.
1. People lack of complement, suffer from disorder of hormones or influenced by genetic factors.
2. In daily life, people get infected unconsciously, or eat something wrong.
3. People take in something toxic or influenced by excessive ultraviolet rays.
4. Due to genetic factors and environmental factors, they interact each other in the body, which leads to more abnormal condition in the body, thus invading kidney and forming lupus nephritis.
Once diagnosed with Lupus Nephritis, people need not worry. In our Hospital, we have immunotherapy which can treat it effectively. Generally, immunotherapy can be divided into 6 steps: immune diagnosis, immune clearance, immune inhibition, immune tolerance, immune adjustment and immune protection.
1. People lack of complement, suffer from disorder of hormones or influenced by genetic factors.
2. In daily life, people get infected unconsciously, or eat something wrong.
3. People take in something toxic or influenced by excessive ultraviolet rays.
4. Due to genetic factors and environmental factors, they interact each other in the body, which leads to more abnormal condition in the body, thus invading kidney and forming lupus nephritis.
Once diagnosed with Lupus Nephritis, people need not worry. In our Hospital, we have immunotherapy which can treat it effectively. Generally, immunotherapy can be divided into 6 steps: immune diagnosis, immune clearance, immune inhibition, immune tolerance, immune adjustment and immune protection.
What Is Chinese Medicine Treatment for Membranous Nephropathy
Membranous Nephropathy can also be called Membranous renal gloemerular nephritis, the name of which is on the basis of renal biopsy. Membranous nephropathy is a kidney disorder that leads to changes and inflammation of the structures inside the kidney that help filter wastes and fluids. The inflammation may lead to problems with kidney function.
Membranous nephropathy is caused by the thickening of part of the glomerular basement membrane. The glomerular basement membrane is a part of the kidneys that helps filter waste and extra fluid from the blood. The thicker glomerular membrane does not work normally. Large amounts of protein are lost in the urine as a result. When other symptoms follow, such as edema, hypoalbuminemia and hyperlipidaemia, it will be called nephrotic syndrome.
How to treat Membranous Nephropathy fundamentally? As we mentioned above, the thickened and then damaged glomerular basement membrane. With the immune complex deposits there, the permeability of renal glomerular membrane increased, which leads to the leaking out of proteins. So in this case, we should use Chinese medicine which can not only repair the damaged intrinsic cells but also clear away the immune complex and increase the immunity of the body.
Firstly, in Chinese medicine or Chinese Medicine, which is the specific therapy, there are active and nutritious herbs which can promote the blood circulation, dissolve the stasis in the blood, improve the micro-blood circulation, discharge the toxins such as creatinine, etc, which can decrease the permeability of renal glomerular membrane, thus stopping the leaking out of protein.
Secondly, Chinese Medicine, there are also many active substances or herbs which can clear away the immune complex which deposits onto the renal glomerular membrane, repair the damaged intrinsic cells and increase the immunity at the same time.
This is about the Chinese medicine for Membranous Nephropathy.
Membranous nephropathy is caused by the thickening of part of the glomerular basement membrane. The glomerular basement membrane is a part of the kidneys that helps filter waste and extra fluid from the blood. The thicker glomerular membrane does not work normally. Large amounts of protein are lost in the urine as a result. When other symptoms follow, such as edema, hypoalbuminemia and hyperlipidaemia, it will be called nephrotic syndrome.
How to treat Membranous Nephropathy fundamentally? As we mentioned above, the thickened and then damaged glomerular basement membrane. With the immune complex deposits there, the permeability of renal glomerular membrane increased, which leads to the leaking out of proteins. So in this case, we should use Chinese medicine which can not only repair the damaged intrinsic cells but also clear away the immune complex and increase the immunity of the body.
Firstly, in Chinese medicine or Chinese Medicine, which is the specific therapy, there are active and nutritious herbs which can promote the blood circulation, dissolve the stasis in the blood, improve the micro-blood circulation, discharge the toxins such as creatinine, etc, which can decrease the permeability of renal glomerular membrane, thus stopping the leaking out of protein.
Secondly, Chinese Medicine, there are also many active substances or herbs which can clear away the immune complex which deposits onto the renal glomerular membrane, repair the damaged intrinsic cells and increase the immunity at the same time.
This is about the Chinese medicine for Membranous Nephropathy.
Why People Get Lupus Nephritis
People who are diagnosed with Lupus Nephritis want to know why they get this disease. Lupus Nephropathy is a kind of autoimmune vasculitis disease, which can influence more than one system and organs. The manifestation of Lupus Nephropathy varies, among which, renal glomerular epithelial cells are damaged. After that, the barrier of renal glomerulus is damaged, which leads to the leaking out of protein into urine.
The pathological mechanism of Lupus Nephritis is also complicated, which is connected with genetics, hormone, environment, medicine, food, and so on. Generally, the pathological factors can be divided into the following three aspects.
Firstly, patients lack complement, disorder of hormone or genetic factors.
Secondly, in daily life, patients get infected carelessly or eat something wrong, or take in medicine which is not suitable, touch toxic things or have more UVB, and so on.
Thirdly, genetic factors and environmental factors interact each other, which leads to more abnormal immune reaction and the occurrence of SLE, thus damaging kidney organs.
Patients with Lupus Nephropathy have red blood cells, white blood cells and protein in urine, high blood pressure. In addition, patients can also have symptoms in gastrointestinal tract, which are such as nausea, abdominal pain, liver or spleen becoming bigger account for 30-40%.
So many sufferings torture Lupus Nephropathy patients. But please do not worry. We have effective treatment measures to treat it.
On the basis that it is an autoimmune disease, we created immunotherapy, which can not only control the condition but also help repair the damaged intrinsic cells and increased immune ability. It can be divided into 6 steps: immune diagnosis, immune clearance, immune inhibition, immune tolerance, immune adjustment and immune protection. In immune clearance step, patients with SLE should clear away the immune complex in the blood, which can supply a cleaner inner environment for the treatment of kidney disease. For patients with SLE, the most proper and critical blood purification method is the plasma exchange, which can supply a good condition for the following treatment.
The pathological mechanism of Lupus Nephritis is also complicated, which is connected with genetics, hormone, environment, medicine, food, and so on. Generally, the pathological factors can be divided into the following three aspects.
Firstly, patients lack complement, disorder of hormone or genetic factors.
Secondly, in daily life, patients get infected carelessly or eat something wrong, or take in medicine which is not suitable, touch toxic things or have more UVB, and so on.
Thirdly, genetic factors and environmental factors interact each other, which leads to more abnormal immune reaction and the occurrence of SLE, thus damaging kidney organs.
Patients with Lupus Nephropathy have red blood cells, white blood cells and protein in urine, high blood pressure. In addition, patients can also have symptoms in gastrointestinal tract, which are such as nausea, abdominal pain, liver or spleen becoming bigger account for 30-40%.
So many sufferings torture Lupus Nephropathy patients. But please do not worry. We have effective treatment measures to treat it.
On the basis that it is an autoimmune disease, we created immunotherapy, which can not only control the condition but also help repair the damaged intrinsic cells and increased immune ability. It can be divided into 6 steps: immune diagnosis, immune clearance, immune inhibition, immune tolerance, immune adjustment and immune protection. In immune clearance step, patients with SLE should clear away the immune complex in the blood, which can supply a cleaner inner environment for the treatment of kidney disease. For patients with SLE, the most proper and critical blood purification method is the plasma exchange, which can supply a good condition for the following treatment.
Thursday, May 23, 2013
Treatment for Lupus Eritematoso Sistémico
Lupus Eritematoso Sistémico is a kind of autoimmune disease, which can lead to systematic damage in kinds of organs. The manifestations in clinic are usually fever, red butterfly scar in face, rash, dental ulcer, arthritis, and so on, which are tormenting patients. Patients with Lupus Eritematoso Sistémico are seeking for a better treatment for it.
Firstly, let’s look at the mechanism of Lupus Eritematoso Sistémico. The forming and deposition of immune complex is the main mechanism which leads to kidney damage caused by Lupus Eritematoso Sistémico. Some antigens such as virus from outside and inner antigen such as DNA influence the immune adjustment function, which make beta lymphocyte active and proliferate, thus creating a large amount of autoantibody. They deposit onto the kidney, thus leading to the damage of renal glomeruli.
So from the above, we can get a conclusion that it is the deposition of immune complex that leads to Lupus Eritematoso Sistémico. Of course, the formation of immune complex on the kidney is due to the immune problem.
On the basis of this, in our Hospital, the experts researched out a therapy called immunotherapy, which can be divided into 6 steps mainly. The first one is scientific diagnosis, which helps us find out exactly where the immune complex deposits, and the type of immune complex.
The second step is immune clearance. With the help of dialysis, plasma exchange and so on, the immune complex can be cleared away. Although the immune complex is cleared away, there are also damaged intrinsic cells, which lead to a new circle of immune response. So the third step is immune tolerance, which means our body must try our best to adapt ourselves to the existence of immune complex. At the same time, we try our best to solve the problem. In the fourth step, we use many medicines to adjust the conflicts, which include both western medicine such as stem cell and Chinese medicine such as Chinese Medicine. The main function of Chinese Medicine is to improve the blood circulation, especially the micro-blood circulation, and dissolve the blood stasis, thus increasing the immune ability. In the last step, patients will come into immune protection stage, which means that we use some medicine which can benefit qi and blood, thus increasing the immune.
The above mentioned steps are about the immunotherapy in our hospital. Patients with Lupus Eritematoso Sistémico can relieve better after these.
Firstly, let’s look at the mechanism of Lupus Eritematoso Sistémico. The forming and deposition of immune complex is the main mechanism which leads to kidney damage caused by Lupus Eritematoso Sistémico. Some antigens such as virus from outside and inner antigen such as DNA influence the immune adjustment function, which make beta lymphocyte active and proliferate, thus creating a large amount of autoantibody. They deposit onto the kidney, thus leading to the damage of renal glomeruli.
So from the above, we can get a conclusion that it is the deposition of immune complex that leads to Lupus Eritematoso Sistémico. Of course, the formation of immune complex on the kidney is due to the immune problem.
On the basis of this, in our Hospital, the experts researched out a therapy called immunotherapy, which can be divided into 6 steps mainly. The first one is scientific diagnosis, which helps us find out exactly where the immune complex deposits, and the type of immune complex.
The second step is immune clearance. With the help of dialysis, plasma exchange and so on, the immune complex can be cleared away. Although the immune complex is cleared away, there are also damaged intrinsic cells, which lead to a new circle of immune response. So the third step is immune tolerance, which means our body must try our best to adapt ourselves to the existence of immune complex. At the same time, we try our best to solve the problem. In the fourth step, we use many medicines to adjust the conflicts, which include both western medicine such as stem cell and Chinese medicine such as Chinese Medicine. The main function of Chinese Medicine is to improve the blood circulation, especially the micro-blood circulation, and dissolve the blood stasis, thus increasing the immune ability. In the last step, patients will come into immune protection stage, which means that we use some medicine which can benefit qi and blood, thus increasing the immune.
The above mentioned steps are about the immunotherapy in our hospital. Patients with Lupus Eritematoso Sistémico can relieve better after these.
Why Lupus Nephritis Patients Have Poor Urine Output
Lupus Nephritis can also be called SLE, a kind of kidney damage or kidney disorder which is caused by the spread of lupus in the body. In normal condition, people have 2000 to 2500 ml urine in 24 hours. However, for patients with Lupus Nephropathy, they can have less than 400 ml urine with 24 hours in the advanced stage of SLE, which is called poor urine.
Why does poor urine take place on patients with Lupus Nephritis? As we know, kidney has an important function: filtration. It can filtrate blood, thus causing urine every day after the reabsorption of renal tubules. After kidney is damaged, the filtration function will also be damaged accordingly, thus causing poor urine output, which usually takes place at the advanced stage of Lupus Nephropathy.
Can poor urine output be improved? Of course. Please do not worry. As long as there is urine, we can take measure to increase the renal glomerular filtration rate.
What should Lupus Nephropathy patients with poor urine do if they want to treat in our Hospital? Firstly, patients should have a systematic examination such as blood test, urine test, ECT and so on, which can show some index such as serum creatinine, GFR, etc, which can give us a general conclusion. In addition, they should also have an immune diagnosis so as to let doctors know how much the damage is, etc. Secondly, after immune diagnosis, patients with poor urine come into immune clearance stage, blood purification especially plasma exchange is applied, which can help clear away the immune complex and create a cleaner environment for the next steps. Next, patients will receive immune adjustment and immune protection, in which, Chinese Medicine and stem cells are applied, which can not only repair the damaged intrinsic cells but also increase the immunity, thus increasing GFR and dissolving poor urine output fundamentally.
Why does poor urine take place on patients with Lupus Nephritis? As we know, kidney has an important function: filtration. It can filtrate blood, thus causing urine every day after the reabsorption of renal tubules. After kidney is damaged, the filtration function will also be damaged accordingly, thus causing poor urine output, which usually takes place at the advanced stage of Lupus Nephropathy.
Can poor urine output be improved? Of course. Please do not worry. As long as there is urine, we can take measure to increase the renal glomerular filtration rate.
What should Lupus Nephropathy patients with poor urine do if they want to treat in our Hospital? Firstly, patients should have a systematic examination such as blood test, urine test, ECT and so on, which can show some index such as serum creatinine, GFR, etc, which can give us a general conclusion. In addition, they should also have an immune diagnosis so as to let doctors know how much the damage is, etc. Secondly, after immune diagnosis, patients with poor urine come into immune clearance stage, blood purification especially plasma exchange is applied, which can help clear away the immune complex and create a cleaner environment for the next steps. Next, patients will receive immune adjustment and immune protection, in which, Chinese Medicine and stem cells are applied, which can not only repair the damaged intrinsic cells but also increase the immunity, thus increasing GFR and dissolving poor urine output fundamentally.
Poor Urine output and Lupus Nephritis
Poor urine output makes Lupus Nephritis patients anxious. Do not worry. As long as we figure out the reason, we can take measures to treat it.
1. With the development of Lupus Nephritis, renal function is damaged, which makes the urine amount reduce, the diseases of which are such as acute renal glomerular nephritis, renal tumor, renal failure. If poor urine is caused by the above reasons, it indicates that the condition is serious.
2. When the blood which flows into kidney reduces, or when Lupus Nephritis patients have bleeding due to wound, shock, heart failure, and so on, patients can also suffer from renal failure, and have poor urine.
3. If Lupus Nephritis patients suffer from block of urinary tract, and patients don’t solve it in time, with time passing by, there will be water in renal pelvis, thus causing poor urine output.
Patients with Lupus Nephritis with poor urine should have a test about the serum creatinine, which is a relatively scientific index which can show how renal function is damaged. In addition, if it is convenient, patients can also have an ECT test, which is even more scientific diagnosis for patients with renal disease.
If it is caused by renal failure, we should treat it as kidney disease. In our hospital, we have immunotherapy for Lupus Nephritis is an auto-immune disease. In renal failure stage, patients have red blood cells, white blood cells and protein in urine, high blood pressure, rash and so on.
The immunotherapy can be divided into 6 steps: immune diagnosis, immune clearance, immune inhibition, immune tolerance, immune adjustment and immune protection.
Immune diagnosis can help us find out where the immune complex, the amount of immune complex, which can also supply an evidence for the treatment plan for the doctors in clinic.
Immune clearance is applied, such as blood dialysis, blood filtration, blood perfusion and plasma exchange, etc. For patients with Lupus Nephritis, they should choose plasma exchange in particular for plasma exchange can change the blood, thus clearing away the immune complex.
Immune adjustment and immune protection is operated by the application of Chinese Medicine and stem cells, etc, which can improve the blood circulation, dissolve the stasis, clear away the immune complex and increase the immunity.
After these, renal function can revive and poor urine can relieve.
1. With the development of Lupus Nephritis, renal function is damaged, which makes the urine amount reduce, the diseases of which are such as acute renal glomerular nephritis, renal tumor, renal failure. If poor urine is caused by the above reasons, it indicates that the condition is serious.
2. When the blood which flows into kidney reduces, or when Lupus Nephritis patients have bleeding due to wound, shock, heart failure, and so on, patients can also suffer from renal failure, and have poor urine.
3. If Lupus Nephritis patients suffer from block of urinary tract, and patients don’t solve it in time, with time passing by, there will be water in renal pelvis, thus causing poor urine output.
Patients with Lupus Nephritis with poor urine should have a test about the serum creatinine, which is a relatively scientific index which can show how renal function is damaged. In addition, if it is convenient, patients can also have an ECT test, which is even more scientific diagnosis for patients with renal disease.
If it is caused by renal failure, we should treat it as kidney disease. In our hospital, we have immunotherapy for Lupus Nephritis is an auto-immune disease. In renal failure stage, patients have red blood cells, white blood cells and protein in urine, high blood pressure, rash and so on.
The immunotherapy can be divided into 6 steps: immune diagnosis, immune clearance, immune inhibition, immune tolerance, immune adjustment and immune protection.
Immune diagnosis can help us find out where the immune complex, the amount of immune complex, which can also supply an evidence for the treatment plan for the doctors in clinic.
Immune clearance is applied, such as blood dialysis, blood filtration, blood perfusion and plasma exchange, etc. For patients with Lupus Nephritis, they should choose plasma exchange in particular for plasma exchange can change the blood, thus clearing away the immune complex.
Immune adjustment and immune protection is operated by the application of Chinese Medicine and stem cells, etc, which can improve the blood circulation, dissolve the stasis, clear away the immune complex and increase the immunity.
After these, renal function can revive and poor urine can relieve.
Why SLE Has Ankle Edema
Why do patients with SLE have ankle edema? Edema in ankle is really a common and typical symptom in patients with SLE. In addition, patients can still have edema in face or eyelids. Generally, renal edema can be caused by two factors.
On one hand, the renal glomerular filtrate rate decreases, but the absorption of water and sodium in renal tubules is normal, which leads to the retention of water and sodium, thus causing the increased permeability of the capillaries in the whole body. In this case, water retention appears in the tissue space. The above condition is usually seen in glomerular nephritis.
On the other hand, with the development of SLE, a large amount of proteinuria appears, in which protein is lost, which leads to low protein in plasma. The osmotic pressure in plasma declines, so liquid flows and edema comes into being. In this case, ankle edema will also appear accordingly.
On one hand, the renal glomerular filtrate rate decreases, but the absorption of water and sodium in renal tubules is normal, which leads to the retention of water and sodium, thus causing the increased permeability of the capillaries in the whole body. In this case, water retention appears in the tissue space. The above condition is usually seen in glomerular nephritis.
On the other hand, with the development of SLE, a large amount of proteinuria appears, in which protein is lost, which leads to low protein in plasma. The osmotic pressure in plasma declines, so liquid flows and edema comes into being. In this case, ankle edema will also appear accordingly.
Monday, May 20, 2013
Lupus Nephritis Prognosis
Patients who are diagnosed with Lupus Nephritis will be concerned about the prognosis, wondering how it develops. Generally speaking, several years ago, most patients with Lupus Nephritis could not get a good prognosis if not treated well and about 20% of them would develop into renal failure after 10 years due to the activity of lupus, which makes people desperate.
However, with the medical technology developing, some scholars point out that about 50% of patients with Lupus Nephritis die of the disease. To our surprise, the other 50% patients die from the untoward effects which are caused by treatment such as hormone. Especially in recent years, Lupus Nephritis can be diagnosed earlier, so treatment schedule can be made accordingly, which makes patients with Lupus Nephritis have a better prognosis. So patients with Lupus Nephritis should be confident.
In addition, experts in this field also point out that infection is also an important factor which leads to the death of patients. So preventing infection is also a critical factor which doctors should pay more attention to. Infection prevention has become an important means to control the condition.
From the above, we can get a conclusion that three factors lead to the prognosis, which are activity of lupus, hormone and infection. What measures shall we take? To treat it, we should not use hormone any more and we should choose another one, which we will mainly explain in detail in this passage.
Lupus Nephritis is an autoimmune disease, so we mainly use immunotherapy, which can be divided into six steps: immune diagnosis, immune clearance, immune inhibition, immune tolerance, immune adjustment and immune protection. In these steps, Chinese Medicine is applied, which avoid the side effects which hormones lead in western countries. After these steps, not only immune complex is cleared but also immunity increases, thus stopping the recurrence of Lupus Nephritis.
However, with the medical technology developing, some scholars point out that about 50% of patients with Lupus Nephritis die of the disease. To our surprise, the other 50% patients die from the untoward effects which are caused by treatment such as hormone. Especially in recent years, Lupus Nephritis can be diagnosed earlier, so treatment schedule can be made accordingly, which makes patients with Lupus Nephritis have a better prognosis. So patients with Lupus Nephritis should be confident.
In addition, experts in this field also point out that infection is also an important factor which leads to the death of patients. So preventing infection is also a critical factor which doctors should pay more attention to. Infection prevention has become an important means to control the condition.
From the above, we can get a conclusion that three factors lead to the prognosis, which are activity of lupus, hormone and infection. What measures shall we take? To treat it, we should not use hormone any more and we should choose another one, which we will mainly explain in detail in this passage.
Lupus Nephritis is an autoimmune disease, so we mainly use immunotherapy, which can be divided into six steps: immune diagnosis, immune clearance, immune inhibition, immune tolerance, immune adjustment and immune protection. In these steps, Chinese Medicine is applied, which avoid the side effects which hormones lead in western countries. After these steps, not only immune complex is cleared but also immunity increases, thus stopping the recurrence of Lupus Nephritis.
End stage Renal Disease due to Lupus Nephritis
Lupus nephritis is an inflammation of the kidney caused by systemic lupus erythematosus (SLE), a disease of the immune system. Apart from the kidneys, SLE can also damage the skin, joints, nervous system and virtually any organ or system in the body.
With time passing by, if patients can not receive effective treatment, it will develop into end stage of renal disease, which can also be called uremia. In this stage, there are not only healthy and damaged intrinsic cells but also necrotic cells in the kidney. On the basis of its pathological mechanism, we researched out immunotherapy, which can be divided into 6 steps: immune diagnosis, immune clearance, immune inhibition, immune tolerance, immune adjustment and immune protection.
1. immune diagnosis
After a systematic diagnosis, we can figure out where the immune complex deposits exactly, the amount of immune complex and the exact type of immune response so that doctors can get more scientific diagnosis and arrange better treatment.
2. immune clearance
In immune clearance step, patients with SLE should clear away the immune complex in the blood, which can supply a cleaner inner environment for the treatment of kidney disease. For patients with SLE, the most proper blood purification method is the plasma exchange. Pay attention that the immune complex we clean is the one in the blood not the one on the kidney.
3. immune inhibition
The third one is immune inhibition. There is immune complex which deposit onto kidney, which leads to immune response. Medicine is used, which can stop the excessive immune response, thus stopping the inflammation response at a rapid speed.
4. immune tolerance
After immune inhibition, the immune response can be stopped. And the damage to the kidney can be blocked. However, the immune complex still deposit onto the kidney, which leads to a new series of immune response.
5. immune adjustment
In this step, Chinese medicines are applied, which can improve the blood circulation, including micro-blood circulation and dissolve the blood stasis. In this case, the immune complex can be discharged out, and the immune system can be repaired. Note that in this step, the immune complex we clean is the one on the kidney not the one in the blood. Blood purification such as dialysis and plasma exchange can not achieve this.
6. immune protection
In this stage, we use medicine which can nourish Qi and blood to rebuild the intrinsic immune system. In addition, biochemical cell therapy is also used in clinic such as the transplant of stem cell, which can also help achieve this effect.
After these steps, end stage of renal disease caused by lupus nephritis can relieve and the symptoms will disappear gradually.
With time passing by, if patients can not receive effective treatment, it will develop into end stage of renal disease, which can also be called uremia. In this stage, there are not only healthy and damaged intrinsic cells but also necrotic cells in the kidney. On the basis of its pathological mechanism, we researched out immunotherapy, which can be divided into 6 steps: immune diagnosis, immune clearance, immune inhibition, immune tolerance, immune adjustment and immune protection.
1. immune diagnosis
After a systematic diagnosis, we can figure out where the immune complex deposits exactly, the amount of immune complex and the exact type of immune response so that doctors can get more scientific diagnosis and arrange better treatment.
2. immune clearance
In immune clearance step, patients with SLE should clear away the immune complex in the blood, which can supply a cleaner inner environment for the treatment of kidney disease. For patients with SLE, the most proper blood purification method is the plasma exchange. Pay attention that the immune complex we clean is the one in the blood not the one on the kidney.
3. immune inhibition
The third one is immune inhibition. There is immune complex which deposit onto kidney, which leads to immune response. Medicine is used, which can stop the excessive immune response, thus stopping the inflammation response at a rapid speed.
4. immune tolerance
After immune inhibition, the immune response can be stopped. And the damage to the kidney can be blocked. However, the immune complex still deposit onto the kidney, which leads to a new series of immune response.
5. immune adjustment
In this step, Chinese medicines are applied, which can improve the blood circulation, including micro-blood circulation and dissolve the blood stasis. In this case, the immune complex can be discharged out, and the immune system can be repaired. Note that in this step, the immune complex we clean is the one on the kidney not the one in the blood. Blood purification such as dialysis and plasma exchange can not achieve this.
6. immune protection
In this stage, we use medicine which can nourish Qi and blood to rebuild the intrinsic immune system. In addition, biochemical cell therapy is also used in clinic such as the transplant of stem cell, which can also help achieve this effect.
After these steps, end stage of renal disease caused by lupus nephritis can relieve and the symptoms will disappear gradually.
Nephrotic Syndrome Secondary to SLE
What shall we do to treat Nephrotic Syndrome which is Secondary to SLE (Systemic Lupus Erythematosus)? Firstly, let’s know something about Systemic Lupus Erythematosus, which is the primary disease and causes Nephrotic Syndrome. people who are suffering from Nephrotic Syndrome Secondary to SLE must be told that it is an immune disease. What is immune disease? Generally speaking, immune disease means that it is the immune system out of order that causes the disease. In normal condition, our immune system is normal, which protects us and prevents us from getting caught by the disease. In order to figure out the solution of Nephrotic Syndrome Secondary to SLE, we should know about the reason why people are caught by kidney disease and there is no doubt that Nephrotic Syndrome is a kind of renal glomerular disease, which is a big group of kidney disease.
Now let’s come back to the question again: why people suffer from kidney disease.
Patients who have been suffering from kidney disease must know about a term immune complex, which is the combination of antigen and antibody. The deposition of the immune complex on the kidney cells or kidney tissues leads to the immune response or inflammatory reaction. If the immune system is abnormal, either intrinsic immune system or spare immune system is abnormal, the immune response or inflammatory reaction will never stop. In this case, on one hand, the immune complex can not be cleared away, on the other hand, the intrinsic cells and tissues in the kidney will be damaged. So it is generally believed that the key point of kidney disease treatment is to clear away the immune complex, which leads to the immune response even too allergic immune response.
However, in the whole world, experts in kidney disease research field have not found out an effective treatment method which can clear away the immune complex thoroughly. So we have to try to stop the immune reaction. To our disappointment, in most of time, immune reaction can not stopped either. Even sometimes, the immune reaction is controlled, there is still immune complex which deposit on the kidney, leading to a new circle of immune complex. At last, people may even develop into renal failure stage.
So how should we treat immune disease on earth? In our Hospital, we have created a new method which is both based on the western technology and traditional Chinese medicine. It can be divided into 6 steps: scientific diagnosis, scientific medicine, immune tolerance, immune adjustment and immune protection and immune clearance.
From the above, we can have known about the mechanism of kidney disease. And accordingly, we can also understand the reason why Nephrotic Syndrome Secondary to SLE takes place. For more information about the six-step therapy, please consult us online.
Now let’s come back to the question again: why people suffer from kidney disease.
Patients who have been suffering from kidney disease must know about a term immune complex, which is the combination of antigen and antibody. The deposition of the immune complex on the kidney cells or kidney tissues leads to the immune response or inflammatory reaction. If the immune system is abnormal, either intrinsic immune system or spare immune system is abnormal, the immune response or inflammatory reaction will never stop. In this case, on one hand, the immune complex can not be cleared away, on the other hand, the intrinsic cells and tissues in the kidney will be damaged. So it is generally believed that the key point of kidney disease treatment is to clear away the immune complex, which leads to the immune response even too allergic immune response.
However, in the whole world, experts in kidney disease research field have not found out an effective treatment method which can clear away the immune complex thoroughly. So we have to try to stop the immune reaction. To our disappointment, in most of time, immune reaction can not stopped either. Even sometimes, the immune reaction is controlled, there is still immune complex which deposit on the kidney, leading to a new circle of immune complex. At last, people may even develop into renal failure stage.
So how should we treat immune disease on earth? In our Hospital, we have created a new method which is both based on the western technology and traditional Chinese medicine. It can be divided into 6 steps: scientific diagnosis, scientific medicine, immune tolerance, immune adjustment and immune protection and immune clearance.
From the above, we can have known about the mechanism of kidney disease. And accordingly, we can also understand the reason why Nephrotic Syndrome Secondary to SLE takes place. For more information about the six-step therapy, please consult us online.
Why do People Get Lupus Nephritis
Definition
Lupus Nephritis is a kind of kidney damage which is caused by Systematic Lupus Nephritis. Systematic Lupus Nephritis (SLE) is also a kind of immune disease. In addition, from cytology, Systematic Lupus Nephritis is a kind of renal epithelial cell disease of capillary vessels. At present, doctors judge the disease by this.
Pathological factors
After patients are infected by lupus, excessive immune response will come into being and exist, which leads to the pathological self-antibody. In this case, a large amount of immune complex comes into being. C3、lgG、lgM and so on will deposit on renal capillary epithelial cells. At this time, the immune mediator in renal capillary epithelial cells will come into being, so the normal function of renal capillary epithelial cells will be damaged as well. There are negative charges barrier in the epithelial cells. After the function is damaged, protein will pass and flow into urine, thus causing proteinuria. From the urine report, we can find out that there are pluses. Renal function will be damaged accordingly.
Treatment principle
To treat Systematic Lupus Nephritis (SLE), we should follow the following procedures.
Firstly, extending blood vessels, the purpose of which is to improve the blood circulation in the kidney, relieve the insufficiency of blood and oxygen in the blood, thus creating a favorable environment for the repair of epithelial cells and mesangial cells.
Secondly, anti-inflammation, the purpose of which is to reduce the infiltration of inflammatory cells and relieve the further damage of renal epithelial cells.
Thirdly, anticoagulation, the purpose of which is to relieve of pressure which forms thrombus and lay a foundation for the repair of epithelial cells.
Fourthly, degradation, which is used to clear the immune complex and matrix and helps them discharge out of the body.
Medicines
As for the medicine, patients with Systematic Lupus Nephritis (SLE) are recommended to take combination of western medicine and Chinese medicine, which can achieve better effect than only either of them for either western medicine or Chinese medicine has restriction. In our hospital, we have created six-step immune therapy on the basis of this theory, which can repair the damaged intrinsic cells as well as increase the immune ability.
Lupus Nephritis is a kind of kidney damage which is caused by Systematic Lupus Nephritis. Systematic Lupus Nephritis (SLE) is also a kind of immune disease. In addition, from cytology, Systematic Lupus Nephritis is a kind of renal epithelial cell disease of capillary vessels. At present, doctors judge the disease by this.
Pathological factors
After patients are infected by lupus, excessive immune response will come into being and exist, which leads to the pathological self-antibody. In this case, a large amount of immune complex comes into being. C3、lgG、lgM and so on will deposit on renal capillary epithelial cells. At this time, the immune mediator in renal capillary epithelial cells will come into being, so the normal function of renal capillary epithelial cells will be damaged as well. There are negative charges barrier in the epithelial cells. After the function is damaged, protein will pass and flow into urine, thus causing proteinuria. From the urine report, we can find out that there are pluses. Renal function will be damaged accordingly.
Treatment principle
To treat Systematic Lupus Nephritis (SLE), we should follow the following procedures.
Firstly, extending blood vessels, the purpose of which is to improve the blood circulation in the kidney, relieve the insufficiency of blood and oxygen in the blood, thus creating a favorable environment for the repair of epithelial cells and mesangial cells.
Secondly, anti-inflammation, the purpose of which is to reduce the infiltration of inflammatory cells and relieve the further damage of renal epithelial cells.
Thirdly, anticoagulation, the purpose of which is to relieve of pressure which forms thrombus and lay a foundation for the repair of epithelial cells.
Fourthly, degradation, which is used to clear the immune complex and matrix and helps them discharge out of the body.
Medicines
As for the medicine, patients with Systematic Lupus Nephritis (SLE) are recommended to take combination of western medicine and Chinese medicine, which can achieve better effect than only either of them for either western medicine or Chinese medicine has restriction. In our hospital, we have created six-step immune therapy on the basis of this theory, which can repair the damaged intrinsic cells as well as increase the immune ability.
Sunday, May 19, 2013
Stem Cell and Lupus Nephritis Stage 4
Patients who are in stage 4 of Lupus Nephritis may fall in desperate and think that they some day may lost their life. Please do not worry, and we will explain it for you in detail and recommend a good treatment method for you.
Systemic Lupus Erythematosus (SLE) is an autoimmune disease, which occurs every now and then, and becomes worse and worse with the recurrence. In stage 4 of chronic kidney disease, patients with lupus nephritis usually have symptoms such as red blood cells, white blood cells and protein in urine, high blood pressure, rash, especially butterfly rash on the face, anemia and so on, all of which make people with Lupus Nephritis suffer and lose confidence for many of them have already begun to take dialysis due to long time high serum creatinine. After realizing dialysis can not repair the damage inside of the kidney, has some adverse side effects and some complications, patients begin to doubt. In this passage, we would like to introduce a better therapy which is called stem cell therapy.
As we mentioned above, Lupus Nephritis is an autoimmune disease. Autoantibody can protect us when pathological factors invade such as bacteria and virus, which can not react to the tissues and elements of our body. It plays functions depending on the tolerance of the whole immune. One the tolerance is damaged, our organic body will consider our own tissues abnormal substances, which leads to autoimmune reaction, causing autoantibody. In normal condition, in the blood, there is a small amount of autoantibody, which will not lead to disease. Once the amount is excess, it will damage the body and leads to kinds of autoimmune disease.
Stem cell’s most important function is differentiation and to increase the immune ability of patients. Stem cell can regenerate into many capillary endothelial cells and repair the damaged renal membrane, repair the filtration membrane, improve the filtration function, thus improving the renal glomerular filtration.
In addition, stem cell can also generate into munologic balance cells such as Ts cells, Th cells, etc. Stem cell can also balance the immunoreaction, diminish a variety of factors which can cause renal glomerular disease, avoid the continuous damage to renal tubules, thus reviving renal function consequently.
Systemic Lupus Erythematosus (SLE) is an autoimmune disease, which occurs every now and then, and becomes worse and worse with the recurrence. In stage 4 of chronic kidney disease, patients with lupus nephritis usually have symptoms such as red blood cells, white blood cells and protein in urine, high blood pressure, rash, especially butterfly rash on the face, anemia and so on, all of which make people with Lupus Nephritis suffer and lose confidence for many of them have already begun to take dialysis due to long time high serum creatinine. After realizing dialysis can not repair the damage inside of the kidney, has some adverse side effects and some complications, patients begin to doubt. In this passage, we would like to introduce a better therapy which is called stem cell therapy.
As we mentioned above, Lupus Nephritis is an autoimmune disease. Autoantibody can protect us when pathological factors invade such as bacteria and virus, which can not react to the tissues and elements of our body. It plays functions depending on the tolerance of the whole immune. One the tolerance is damaged, our organic body will consider our own tissues abnormal substances, which leads to autoimmune reaction, causing autoantibody. In normal condition, in the blood, there is a small amount of autoantibody, which will not lead to disease. Once the amount is excess, it will damage the body and leads to kinds of autoimmune disease.
Stem cell’s most important function is differentiation and to increase the immune ability of patients. Stem cell can regenerate into many capillary endothelial cells and repair the damaged renal membrane, repair the filtration membrane, improve the filtration function, thus improving the renal glomerular filtration.
In addition, stem cell can also generate into munologic balance cells such as Ts cells, Th cells, etc. Stem cell can also balance the immunoreaction, diminish a variety of factors which can cause renal glomerular disease, avoid the continuous damage to renal tubules, thus reviving renal function consequently.
Treatment for Types of Lupus Nephritis
Lupus Nephritis can be caused by three types of lupus. The first one is systemic lupus erythematosus(SLE), which has the most severe symptoms in the early stage among all types of lupus. The clinical manifestations are various and complicated, which can be more serious after the application of hormone and other medicines for a long time. The second type is discoid lupus erythematosus, which can be called DLE for short. It invades skin at first, which makes scarlet spot appear. The size is as big as yellow bean or green bean. The third type of lupus leads to damage in skin as well, which looks node or spots, and lies in the deep derma or subcutaneus adipose tissue. Damage of this kind of lupus can take place in any place such as genal area, buttocks, lower limbs and chest.
No matter where the damage is and which type of lupus it is, it may spread into other organs if not controlled well. When it influences kidney, lupus nephritis or lupus nephropathy will take place. Lupus nephritis or lupus nephropathy is autoimmune disease, which can be treated well with the help of immunotherapy, which can be divided into immune diagnosis, immune clearance, immune inhibition, immune tolerance, immune adjustment and immune protection. The immune disorder leads to the retention of immune complex both in blood circulation and on the kidney, which leads to the excessive immune reaction, thus causing damage to the nearby healthy or normal intrinsic cells. So immune clearance is necessary. After that, people with lupus nephritis should also apply medicine which can adjust and make the immune complex on the kidney discharge. Only in this way, can we let the further immune reaction stop. In this step, Chinese medicine is applied, which can benefit Qi and nourish blood.
After that, not only immune reaction will be stopped, but also damaged cells can be repaired. Chinese medicine can also increase the immunity, which can treat lupus nephritis fundamentally. Immunotherapy is the custom therapy in our Hospital, China.
No matter where the damage is and which type of lupus it is, it may spread into other organs if not controlled well. When it influences kidney, lupus nephritis or lupus nephropathy will take place. Lupus nephritis or lupus nephropathy is autoimmune disease, which can be treated well with the help of immunotherapy, which can be divided into immune diagnosis, immune clearance, immune inhibition, immune tolerance, immune adjustment and immune protection. The immune disorder leads to the retention of immune complex both in blood circulation and on the kidney, which leads to the excessive immune reaction, thus causing damage to the nearby healthy or normal intrinsic cells. So immune clearance is necessary. After that, people with lupus nephritis should also apply medicine which can adjust and make the immune complex on the kidney discharge. Only in this way, can we let the further immune reaction stop. In this step, Chinese medicine is applied, which can benefit Qi and nourish blood.
After that, not only immune reaction will be stopped, but also damaged cells can be repaired. Chinese medicine can also increase the immunity, which can treat lupus nephritis fundamentally. Immunotherapy is the custom therapy in our Hospital, China.
MMF recommended for lupus nephritis, refractory SLE
London, UK - Mycophenolate mofetil (MMF) (CellCept, Roche Pharmaceuticals) allowed patients with lupus nephritis or treatment-resistant systemic lupus erythematosus (SLE) to significantly reduce their steroid dosage, was as good as cyclophosphamide (CYC) for maintaining remissions, and is a candidate to become first-line therapy for lupus nephritis, according to data reported by Dr Cecilia N Pisoni (St Thomas's Hospital, London, UK) and colleagues in the June 2005 issue of the Journal of Rheumatology
"MMF appears to be a safe and successful treatment to maintain remission in patients with lupus nephritis and to control overall disease activity," writes Pisoni.
In an editorial commenting on this paper [ 2 ], Drs W Joseph McClune and Mona M Riskalla (University of Michigan, Ann Arbor) conclude that this study "adds support to the use of MMF in patients with both renal and nonrenal SLE." The editorial also reviews several recent trials of MMF in lupus nephritis and, on the basis of all available data, raises a number of points concerning the use of MMF in the treatment of lupus.
Retrospective study of MMF-treated patients
The Pisoni paper is a retrospective study of 93 patients with SLE treated with MMF because of renal involvement (68.6%), uncontrolled disease activity (16.3%), or other SLE-related manifestations. Two patients were excluded because they did not fulfill American College of Rheumatology (ACR) criteria for SLE, and five patients were excluded because of missing data. All patients had taken MMF for at least three months. The average duration of SLE was more than 10 years. Fifty percent of patients had previously received CYC, 87.2% azathioprine, and 11.6% methotrexate treatment.
Over the course of MMF treatment, steroid dose, erythrocyte sedimentation rate (ESR), anti-dsDNA, and European Consensus Lupus Activity Measure (ECLAM) significantly decreased, and complement C3 significantly increased.
Effects of MMF treatment in patients with SLE
Patients with mesangial proliferation (WHO class II) typically present with proteinuria and haematuria. Such patients are usually treated with steroids in the hope of preventing progression to more severe disease although there have been no controlled trials of treatment. Similarly, there have been no controlled trials of treatment of lupus membranous nephropathy, which is found in between 12 and 26% of patients with lupus nephritis. Using the old WHO classification the 10‐year survival free of end‐stage renal failure or death was 72–90% for class Va and Vb (membranous nephropathy with mild mesangial hypercellularity and scattered deposits) [2,3] and 48–81% for WHO class Vc and Vd (membranous nephropathy with focal or diffuse proliferative glomerulonephritis) [2,3]. These patients had been treated with prednisolone and cyclophosphamide or azathioprine. In the revised WHO classification patients with WHO class Vc and Vd (membranous nephropathy with focal or diffuse proliferative glomerulonephritis, respectively) were reclassified as WHO classes III and IV [4]. Our practice is to treat patients with WHO class Va and Vb with prednisolone and to use azathioprine as a steroid sparing agent and to treat patients with WHO class Vc and Vd as for a proliferative lupus nephritis
In the 1960s the 3‐year patient survival in patients with a proliferative lupus nephritis who were treated with steroids was 50–60% [5,6] and patients with these lesions became the focus of the controlled trials of treatment comparing prednisolone alone versus prednisolone and azathioprine or cyclophosphamide. In a narrative review, Donadio and Glassock argued that the addition of immunosuppressants to steroids could not convincingly be shown to confer benefit in terms of preventing end‐stage renal failure or deaths as compared with steroids alone [7]. In a pooled analysis, Felsom and Anderson [8] came to the opposite view and reported that patients receiving immunosuppressive drugs were less likely to develop end‐stage renal failure or to die from this than patients receiving steroids alone. The meta‐analysis carried out by Bansal and Beto [9] concluded that the addition of immunosuppressants (cyclophosphamide or azathioprine) to steroids reduced the risk of dying or of developing end‐stage renal failure as compared with prednisolone alone.
New treatment
The age‐ and dose‐related toxicity of cyclophosphamide with oligospermia in men and premature ovarian failure in women [21,22] together with its oncogenicity has prompted a search for equally effective but less toxic treatment for lupus nephritis. One such drug might be mycophenolate mofetil (MMF), which inhibits the de novo pathway of purine synthesis and therefore lymphocyte proliferation [23]. MMF is an immunosuppressive drug that is of established efficacy in renal transplantation [24].
MMF and lupus nephritis
We have recently reviewed the role of MMF in the treatment of lupus nephritis [25]. There have been several case reports and case series of the use of MMF together with steroids in treating patients with lupus nephritis whose disease was relapsing or was resistant to cyclophosphamide and steroids. In addition, open pilot studies suggested that MMF might have a beneficial role in lupus nephritis. This was confirmed by preliminary analysis of the ongoing pilot study of MMF in the treatment of lupus nephritis organized by the UK Renal Association Clinical Trials Committee [DRW Jayne, personal communication].
Randomized controlled trials of MMF
Chan et al. reported a randomized controlled trial of 42 patients with WHO Class IV lupus nephritis that compared the effect of MMF (1 g twice daily for 6 months, then 0.5 g twice daily for 6 months), and prednisolone with oral cyclophosphamide (2.5 mg/kg daily for 6 months followed by azathioprine (1.5 mg/kg daily) and prednisolone [26]. Both drugs led to comparable rates of complete remission (MMF 81%: cyclophosphamide 76%), partial remission (MMF 14%: cyclophosphamide 14%), deaths (MMF 0%: cyclophosphamide (10%) and relapse (MMF 15%: cyclophosphamide 11%). Infections were more common in the patients treated with cyclophosphamide (33 vs 19%) and amenorrhoea (23%), hair loss (19%) and leukopenia (10%) only occurred in the patients treated with cyclophosphamide. The numbers of patients studied was small and the patients had mild renal impairment. There is, therefore, a requirement for a larger appropriately powered study in patients with proliferative lupus nephritis to study the efficacy and toxicity of prednisolone with MMF as compared with prednisolone and cyclophosphamide.
"MMF appears to be a safe and successful treatment to maintain remission in patients with lupus nephritis and to control overall disease activity," writes Pisoni.
In an editorial commenting on this paper [ 2 ], Drs W Joseph McClune and Mona M Riskalla (University of Michigan, Ann Arbor) conclude that this study "adds support to the use of MMF in patients with both renal and nonrenal SLE." The editorial also reviews several recent trials of MMF in lupus nephritis and, on the basis of all available data, raises a number of points concerning the use of MMF in the treatment of lupus.
Retrospective study of MMF-treated patients
The Pisoni paper is a retrospective study of 93 patients with SLE treated with MMF because of renal involvement (68.6%), uncontrolled disease activity (16.3%), or other SLE-related manifestations. Two patients were excluded because they did not fulfill American College of Rheumatology (ACR) criteria for SLE, and five patients were excluded because of missing data. All patients had taken MMF for at least three months. The average duration of SLE was more than 10 years. Fifty percent of patients had previously received CYC, 87.2% azathioprine, and 11.6% methotrexate treatment.
Over the course of MMF treatment, steroid dose, erythrocyte sedimentation rate (ESR), anti-dsDNA, and European Consensus Lupus Activity Measure (ECLAM) significantly decreased, and complement C3 significantly increased.
Effects of MMF treatment in patients with SLE
Patients with mesangial proliferation (WHO class II) typically present with proteinuria and haematuria. Such patients are usually treated with steroids in the hope of preventing progression to more severe disease although there have been no controlled trials of treatment. Similarly, there have been no controlled trials of treatment of lupus membranous nephropathy, which is found in between 12 and 26% of patients with lupus nephritis. Using the old WHO classification the 10‐year survival free of end‐stage renal failure or death was 72–90% for class Va and Vb (membranous nephropathy with mild mesangial hypercellularity and scattered deposits) [2,3] and 48–81% for WHO class Vc and Vd (membranous nephropathy with focal or diffuse proliferative glomerulonephritis) [2,3]. These patients had been treated with prednisolone and cyclophosphamide or azathioprine. In the revised WHO classification patients with WHO class Vc and Vd (membranous nephropathy with focal or diffuse proliferative glomerulonephritis, respectively) were reclassified as WHO classes III and IV [4]. Our practice is to treat patients with WHO class Va and Vb with prednisolone and to use azathioprine as a steroid sparing agent and to treat patients with WHO class Vc and Vd as for a proliferative lupus nephritis
In the 1960s the 3‐year patient survival in patients with a proliferative lupus nephritis who were treated with steroids was 50–60% [5,6] and patients with these lesions became the focus of the controlled trials of treatment comparing prednisolone alone versus prednisolone and azathioprine or cyclophosphamide. In a narrative review, Donadio and Glassock argued that the addition of immunosuppressants to steroids could not convincingly be shown to confer benefit in terms of preventing end‐stage renal failure or deaths as compared with steroids alone [7]. In a pooled analysis, Felsom and Anderson [8] came to the opposite view and reported that patients receiving immunosuppressive drugs were less likely to develop end‐stage renal failure or to die from this than patients receiving steroids alone. The meta‐analysis carried out by Bansal and Beto [9] concluded that the addition of immunosuppressants (cyclophosphamide or azathioprine) to steroids reduced the risk of dying or of developing end‐stage renal failure as compared with prednisolone alone.
New treatment
The age‐ and dose‐related toxicity of cyclophosphamide with oligospermia in men and premature ovarian failure in women [21,22] together with its oncogenicity has prompted a search for equally effective but less toxic treatment for lupus nephritis. One such drug might be mycophenolate mofetil (MMF), which inhibits the de novo pathway of purine synthesis and therefore lymphocyte proliferation [23]. MMF is an immunosuppressive drug that is of established efficacy in renal transplantation [24].
MMF and lupus nephritis
We have recently reviewed the role of MMF in the treatment of lupus nephritis [25]. There have been several case reports and case series of the use of MMF together with steroids in treating patients with lupus nephritis whose disease was relapsing or was resistant to cyclophosphamide and steroids. In addition, open pilot studies suggested that MMF might have a beneficial role in lupus nephritis. This was confirmed by preliminary analysis of the ongoing pilot study of MMF in the treatment of lupus nephritis organized by the UK Renal Association Clinical Trials Committee [DRW Jayne, personal communication].
Randomized controlled trials of MMF
Chan et al. reported a randomized controlled trial of 42 patients with WHO Class IV lupus nephritis that compared the effect of MMF (1 g twice daily for 6 months, then 0.5 g twice daily for 6 months), and prednisolone with oral cyclophosphamide (2.5 mg/kg daily for 6 months followed by azathioprine (1.5 mg/kg daily) and prednisolone [26]. Both drugs led to comparable rates of complete remission (MMF 81%: cyclophosphamide 76%), partial remission (MMF 14%: cyclophosphamide 14%), deaths (MMF 0%: cyclophosphamide (10%) and relapse (MMF 15%: cyclophosphamide 11%). Infections were more common in the patients treated with cyclophosphamide (33 vs 19%) and amenorrhoea (23%), hair loss (19%) and leukopenia (10%) only occurred in the patients treated with cyclophosphamide. The numbers of patients studied was small and the patients had mild renal impairment. There is, therefore, a requirement for a larger appropriately powered study in patients with proliferative lupus nephritis to study the efficacy and toxicity of prednisolone with MMF as compared with prednisolone and cyclophosphamide.
My 8 Year Old Child Was Diagnosed with SLE
Mrs Smith gets confused because her child Lily who is only 8 years old now, is diagnosed with SLE, which is short for Systemic Lupus Erythematosus. In this passage, we will mainly introduce the pathogenesis, the treatment of SLE, so as to diminish the anxiety of people such as Mrs Smith.
Systemic Lupus Erythematosus is a category for a collection of diseases with similar underlying problems with immunity (autoimmune disease). Symptoms of these diseases can affect many different body systems, including joints, skin, kidneys, blood cells, heart, and lungs. Four main types of lupus exist — systemic lupus Erythematosus, discoid lupus erythematosus, drug-induced Systemic Lupus Erythematosus, and neonatal lupus erythematosus.
In abroad, there are 50 cases among 100, 000 people, and in China, there are 70 cases among 100,000 people. Among those who are diagnosed with Systemic Lupus Erythematosus, young women take up a larger proportion.
However, even if patients are diagnosed with Systemic Lupus Erythematosus, they do not need to be anxious and loose confidence. With the development of modern technology in medical field, there takes place breakthroughs in the treatment of immune disease, including SLE.
One the basis of both western medicine and Chinese traditional medicine, immunotherapy is created in our Hospital, which can be divided into 6 steps, immune diagnosis, immune clearance, immune inhibition, immune tolerance, immune adjustment, and immune protection.
After a systematic diagnosis, we can figure out where the immune complex deposits exactly, the amount of immune complex and the exact type of immune response so that doctors can get more scientific diagnosis and arrange better treatment. Without it, we can not know the dosage of medicine. Less dosage can not achieve the treatment effect while too much can also cause damage to the kidney.
In immune clearance step, patients with SLE should clear away the immune complex in the blood, which can supply a cleaner inner environment for the treatment of kidney disease. For patients with SLE, the most proper blood purification method is the plasma exchange. Pay attention that the immune complex we clean is the one in the blood not the one on the kidney.
The third one is immune inhibition. There is immune complex which deposit onto kidney, which leads to immune response. Medicine is used, which can stop the excessive immune response, thus stopping the inflammation response at a rapid speed.
The fourth one is immune tolerance. After immune inhibition, the immune response can be stopped. And the damage to the kidney can be blocked. However, the immune complex still deposit onto the kidney, which leads to a new series of immune response.
The fifth one is immune adjustment. In this step, Chinese medicines are applied, which can improve the blood circulation, including micro-blood circulation and dissolve the blood stasis. In this case, the immune complex can be discharged out, and the immune system can be repaired. Note that in this step, the immune complex we clean is the one on the kidney not the one in the blood. Blood purification such as dialysis and plasma exchange can not achieve this.
Last but not least, immune protection is applied, in which stage, we use medicine which can nourish qi and blood to rebuild the intrinsic immune system. In addition, biochemical cell therapy is also used in clinic such as the transplant of stem cell, which can also help achieve this effect.
We believe that with this method, patients with SLE can control the condition and remit gradually.
Systemic Lupus Erythematosus is a category for a collection of diseases with similar underlying problems with immunity (autoimmune disease). Symptoms of these diseases can affect many different body systems, including joints, skin, kidneys, blood cells, heart, and lungs. Four main types of lupus exist — systemic lupus Erythematosus, discoid lupus erythematosus, drug-induced Systemic Lupus Erythematosus, and neonatal lupus erythematosus.
In abroad, there are 50 cases among 100, 000 people, and in China, there are 70 cases among 100,000 people. Among those who are diagnosed with Systemic Lupus Erythematosus, young women take up a larger proportion.
However, even if patients are diagnosed with Systemic Lupus Erythematosus, they do not need to be anxious and loose confidence. With the development of modern technology in medical field, there takes place breakthroughs in the treatment of immune disease, including SLE.
One the basis of both western medicine and Chinese traditional medicine, immunotherapy is created in our Hospital, which can be divided into 6 steps, immune diagnosis, immune clearance, immune inhibition, immune tolerance, immune adjustment, and immune protection.
After a systematic diagnosis, we can figure out where the immune complex deposits exactly, the amount of immune complex and the exact type of immune response so that doctors can get more scientific diagnosis and arrange better treatment. Without it, we can not know the dosage of medicine. Less dosage can not achieve the treatment effect while too much can also cause damage to the kidney.
In immune clearance step, patients with SLE should clear away the immune complex in the blood, which can supply a cleaner inner environment for the treatment of kidney disease. For patients with SLE, the most proper blood purification method is the plasma exchange. Pay attention that the immune complex we clean is the one in the blood not the one on the kidney.
The third one is immune inhibition. There is immune complex which deposit onto kidney, which leads to immune response. Medicine is used, which can stop the excessive immune response, thus stopping the inflammation response at a rapid speed.
The fourth one is immune tolerance. After immune inhibition, the immune response can be stopped. And the damage to the kidney can be blocked. However, the immune complex still deposit onto the kidney, which leads to a new series of immune response.
The fifth one is immune adjustment. In this step, Chinese medicines are applied, which can improve the blood circulation, including micro-blood circulation and dissolve the blood stasis. In this case, the immune complex can be discharged out, and the immune system can be repaired. Note that in this step, the immune complex we clean is the one on the kidney not the one in the blood. Blood purification such as dialysis and plasma exchange can not achieve this.
Last but not least, immune protection is applied, in which stage, we use medicine which can nourish qi and blood to rebuild the intrinsic immune system. In addition, biochemical cell therapy is also used in clinic such as the transplant of stem cell, which can also help achieve this effect.
We believe that with this method, patients with SLE can control the condition and remit gradually.
Friday, May 17, 2013
Renal Insufficiency
Renal Insufficiency is caused by many reasons. The renal glomeruli are damaged seriously, which leads to the disorder of electrolyte, acid-base balance. Renal insufficiency can be divided into acute renal insufficiency and chronic renal insufficiency. The prognosis is not good and threatens people’ s life.
The pathogenesis of renal insufficiency
Firstly, renal insufficiency can be caused by kidney disease such as acute kidney failure, chronic kidney failure, pyelonephritis, nephrotuberculosis, renal tubules degeneration caused by chemical toxicant and biological poisons, etc.
Secondly, renal insufficiency can also be caused by barrier in the whole blood circulation such as shock, heart failure, high blood pressure, etc.
Renal insufficiency can be divided into 4 stages.
The third stage is called compensation stage. Because kidney has a strong ability of compensation,symptoms will not occur. Even though some renal glomeruli are damaged, other remained renal glomeruli can still work and do more work to take place those which are damaged. The ability of secretion and electrolyte balance can also meet the need. So in clinic, there is no symptom. In renal function test, we can find out that some index can be in normal range and can be a little high.
In the second stage, we call it renal insufficiency stage. Many glomeruli are damaged in this stage, which account for 60% to 75%. Kidney has difficulties in discharging metabolism. Serum creatinine and BUN (blood urea nitrogen) will become slightly high. Patients can suffer from anemia, fatigue, decreased body weight, and can not concentrate well. All of them can be ignored easily. However, if patients loose water in the body, or suffer from infection, bleeding, etc, their symptoms will appear obviously.
In the third stage, it is called renal failure stage. The damage in the kidney has become rather serious, accounting for 75% to 95%. The inner environment can not maintain stable. In addition, patients will get tired easily and will feel fatigue, and can not concentrate, etc. Anemia is not serious as well. Urine at night becomes more. What’s more, serum creatinine increases. BUN increases as well. Patients can also be accompanied by acidosis. So this stage can also be called azotemia.
In the fourth stage, patients with renal insufficiency develop into advanced stage kidney disease or uremia stage. In this stage, damage of renal glomeruli spreads to 95%. Patients have serious clinical symptoms such as nausea, vomiting, little urine, edema, high blood pressure, serious edema and anemia, itch in skin, and so on.
The pathogenesis of renal insufficiency
Firstly, renal insufficiency can be caused by kidney disease such as acute kidney failure, chronic kidney failure, pyelonephritis, nephrotuberculosis, renal tubules degeneration caused by chemical toxicant and biological poisons, etc.
Secondly, renal insufficiency can also be caused by barrier in the whole blood circulation such as shock, heart failure, high blood pressure, etc.
Renal insufficiency can be divided into 4 stages.
The third stage is called compensation stage. Because kidney has a strong ability of compensation,symptoms will not occur. Even though some renal glomeruli are damaged, other remained renal glomeruli can still work and do more work to take place those which are damaged. The ability of secretion and electrolyte balance can also meet the need. So in clinic, there is no symptom. In renal function test, we can find out that some index can be in normal range and can be a little high.
In the second stage, we call it renal insufficiency stage. Many glomeruli are damaged in this stage, which account for 60% to 75%. Kidney has difficulties in discharging metabolism. Serum creatinine and BUN (blood urea nitrogen) will become slightly high. Patients can suffer from anemia, fatigue, decreased body weight, and can not concentrate well. All of them can be ignored easily. However, if patients loose water in the body, or suffer from infection, bleeding, etc, their symptoms will appear obviously.
In the third stage, it is called renal failure stage. The damage in the kidney has become rather serious, accounting for 75% to 95%. The inner environment can not maintain stable. In addition, patients will get tired easily and will feel fatigue, and can not concentrate, etc. Anemia is not serious as well. Urine at night becomes more. What’s more, serum creatinine increases. BUN increases as well. Patients can also be accompanied by acidosis. So this stage can also be called azotemia.
In the fourth stage, patients with renal insufficiency develop into advanced stage kidney disease or uremia stage. In this stage, damage of renal glomeruli spreads to 95%. Patients have serious clinical symptoms such as nausea, vomiting, little urine, edema, high blood pressure, serious edema and anemia, itch in skin, and so on.
Why Kidney Failure Patients Have Anemia
Why do patients with renal failure patients have anemia? The reasons are as follows:
1. When kidney disorder develops into kidney failure stage, the secretion of EPO will decrease, and the hematopoietic function of marrow will also decline. In normal condition, EPO comes into being in kidney and reach marrow through blood circulation and adjust the production of red blood cells. However, in kidney failure stage, kidney can not produce enough EPO, which lead to the decline of red blood cells in the body, thus leading to anemia.
2. In kidney failure stage, there have been many toxins which accumulate in the blood, which inhibit the hematopoietic function of marrow. We can also say, vicious circle will take place easily if the effective measures are not taken in time.
3. Toxins in the blood will also damage the red blood cell, which leads to hemolysis.
4. In renal failure stage, patients will feel vomiting and nausea, so they will take in less protein, iron and folic acid, which leads to the insufficient supply of materials which is used to produce blood.
5. In renal failure stage, the blood coagulation is blocked, which leads to bleeding, thus worsening anemia.
So patients with kidney failure are suggested to receive treatment as soon as possible so as to prevent other complicaitions. In our Hospital, Chinese Medicine is applied, which is mainly aimed at the relieving of anemia.
Chinese Medicine is abstracted from herbs, which contains active substances and active materials, so it can improve the blood flow in the kidney, including improving the micro-blood circulation.
It can also promote the secretion of EPO, activate the hematopoietic function of marrow, thus relieving anemia. What’s more, Chinese Medicine can also extend the blood vessels in the body, decrease the secretion of renin, which can lower high blood pressure as well.
After the application of Chinese Medicine, anemia and other symptoms such as poor appetite, vomiting can also relieve. For more information, please consult us on line or leave a message and all your information will be kept confidential.
1. When kidney disorder develops into kidney failure stage, the secretion of EPO will decrease, and the hematopoietic function of marrow will also decline. In normal condition, EPO comes into being in kidney and reach marrow through blood circulation and adjust the production of red blood cells. However, in kidney failure stage, kidney can not produce enough EPO, which lead to the decline of red blood cells in the body, thus leading to anemia.
2. In kidney failure stage, there have been many toxins which accumulate in the blood, which inhibit the hematopoietic function of marrow. We can also say, vicious circle will take place easily if the effective measures are not taken in time.
3. Toxins in the blood will also damage the red blood cell, which leads to hemolysis.
4. In renal failure stage, patients will feel vomiting and nausea, so they will take in less protein, iron and folic acid, which leads to the insufficient supply of materials which is used to produce blood.
5. In renal failure stage, the blood coagulation is blocked, which leads to bleeding, thus worsening anemia.
So patients with kidney failure are suggested to receive treatment as soon as possible so as to prevent other complicaitions. In our Hospital, Chinese Medicine is applied, which is mainly aimed at the relieving of anemia.
Chinese Medicine is abstracted from herbs, which contains active substances and active materials, so it can improve the blood flow in the kidney, including improving the micro-blood circulation.
It can also promote the secretion of EPO, activate the hematopoietic function of marrow, thus relieving anemia. What’s more, Chinese Medicine can also extend the blood vessels in the body, decrease the secretion of renin, which can lower high blood pressure as well.
After the application of Chinese Medicine, anemia and other symptoms such as poor appetite, vomiting can also relieve. For more information, please consult us on line or leave a message and all your information will be kept confidential.
Four Stages of Renal Insufficiency in China
In China, we definite the stages of renal insufficiency mainly according to the level of serum creatine. The four stages are mainly as follows: compensation stage, discompensation stage, early stage of renal failure, end stage of renal failure.
In the first stage: compensation stage, there is nearly no symptom in clinic for the kidney has a strong ability of compensation. When some of the renal intrinsic cells are damaged, others will do more work such as filtrating blood, which make serum creatinine is133～177umol/L. In this stage, kidney can still function and work well, so we call it compensation stage. We should pay attention however that there has been damage in the kidney and the GFR has decreased. Kidney can still discharge metabolism product, balance of electrolyte, and so on.
The second stage is discompensation stage. In this stage, serum creatinine is 177～443umol/L. The damaged renal glomerulus increases, which accounts for about 60% to 75%. The secretion function has been damaged, blood urea acid increases as well. Kidney disease patients begin to have anemia, fatigue, weakness, lost body weight, and so on. If they suffer from water lost, infection or bleeding, the condition will develop faster.
The third stage is early stage of renal failure stage. In this stage, the serum creatinine is 443-707umol/L. There are more necrotic renal glomerulus. Renal fibrosis appears in renal tubules-renal parenchyma, renal blood vessels, which leads to serious damage in the kidney. As for the symptoms, kidney disease patients will have more obvious anemia, increased urine at night, and so on.
In the end stage of renal failure, serum creatinine is more than 707umoll/L. In China, patients begin to take dialysis. The damaged renal glomerulus are more than 95%. Patients with kidney disease will also have serious vomiting, little urine, edema, high blood pressure and so on.
In the first stage: compensation stage, there is nearly no symptom in clinic for the kidney has a strong ability of compensation. When some of the renal intrinsic cells are damaged, others will do more work such as filtrating blood, which make serum creatinine is133～177umol/L. In this stage, kidney can still function and work well, so we call it compensation stage. We should pay attention however that there has been damage in the kidney and the GFR has decreased. Kidney can still discharge metabolism product, balance of electrolyte, and so on.
The second stage is discompensation stage. In this stage, serum creatinine is 177～443umol/L. The damaged renal glomerulus increases, which accounts for about 60% to 75%. The secretion function has been damaged, blood urea acid increases as well. Kidney disease patients begin to have anemia, fatigue, weakness, lost body weight, and so on. If they suffer from water lost, infection or bleeding, the condition will develop faster.
The third stage is early stage of renal failure stage. In this stage, the serum creatinine is 443-707umol/L. There are more necrotic renal glomerulus. Renal fibrosis appears in renal tubules-renal parenchyma, renal blood vessels, which leads to serious damage in the kidney. As for the symptoms, kidney disease patients will have more obvious anemia, increased urine at night, and so on.
In the end stage of renal failure, serum creatinine is more than 707umoll/L. In China, patients begin to take dialysis. The damaged renal glomerulus are more than 95%. Patients with kidney disease will also have serious vomiting, little urine, edema, high blood pressure and so on.
Subscribe to:
Posts (Atom)